Retinal astrocytoma regression in tuberous sclerosis patients treated with everolimus

被引：8
|
作者：
Zipori, Anat Bachar [1 ,2 ,3 ]
Tehrani, Nasrin N. [1 ,2 ]
Ali, Asim [1 ,2 ]
机构：
[1] Hosp Sick Children, Dept Ophthalmol & Vis Sci, Toronto, ON, Canada
[2] Univ Toronto, Fac Med, Toronto, ON, Canada
[3] Tel Aviv Sourasky Med Ctr, Dept Ophthalmol, Tel Aviv, Israel
来源：
JOURNAL OF AAPOS | 2018年 / 22卷 / 01期
关键词：
HAMARTOMA; COMPLEX; MULTICENTER;
D O I：
10.1016/j.jaapos.2017.08.009
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Everolimus is an inhibitor of the mammalian target of rapamycin (mTOR) that has been approved by the US Food and Drug Administration for the treatment of subependymal giant cell astrocytoma (SEGA) in patients with tuberous sclerosis complex (TSC). Retinal hamartomas, which are one of the major diagnostic features of TSC, tend to remain stable or gradually progress in the natural history of the disease. We report 2 patients with TSC treated with everolimus for SEGA in whom fundus photographs and spectral domain optical coherence tomography demonstrated regression of previously documented multiple retinal hamartomas in all 4 eyes.
引用
收藏
页码：76 / 79
页数：4
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