Enantioselective Heck reactions using chiral P,N-ligands

被引：131
|
作者：
Loiseleur, O [1 ]
Hayashi, M [1 ]
Keenan, M [1 ]
Schmees, N [1 ]
Pfaltz, A [1 ]
机构：
[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 1999年 / 576卷 / 1-2期
关键词：
asymmetric catalysis; oxazolines; palladium; P; N-ligands;
D O I：
10.1016/S0022-328X(98)01049-3
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Palladium complexes with chiral phosphinooxazoline ligands are efficient catalysts far enantioselective Heck reactions with aryl or alkenyl triflates and cyclic olefins. In the arylation and alkenylation of 1,2-dihydrofuran, cyclopentene, 2,3-dihydro-4H-pyran, 4,7-dihydro-1,3-dioxepin, and N-methoxycarbonyl-2,3-dihydropyrrole high yields and good to excellent enantioselectivities have been obtained. In contrast to palladium-BINAP catalysts, the catalysts derived from phosphinooxazolines show a very low tendency to promote isomerization of the product by C-C double bond migration. (C) 1999 Elsevier Science S.A. All rights reserved.
引用
收藏
页码：16 / 22
页数：7
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