Enantioselective Heck reactions using chiral P,N-ligands

被引：131

作者：

Loiseleur, O ^{[1
]}

Hayashi, M ^{[1
]}

Keenan, M ^{[1
]}

Schmees, N ^{[1
]}

Pfaltz, A ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 1999年 / 576卷 / 1-2期

关键词：

asymmetric catalysis; oxazolines; palladium; P; N-ligands;

D O I：

10.1016/S0022-328X(98)01049-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Palladium complexes with chiral phosphinooxazoline ligands are efficient catalysts far enantioselective Heck reactions with aryl or alkenyl triflates and cyclic olefins. In the arylation and alkenylation of 1,2-dihydrofuran, cyclopentene, 2,3-dihydro-4H-pyran, 4,7-dihydro-1,3-dioxepin, and N-methoxycarbonyl-2,3-dihydropyrrole high yields and good to excellent enantioselectivities have been obtained. In contrast to palladium-BINAP catalysts, the catalysts derived from phosphinooxazolines show a very low tendency to promote isomerization of the product by C-C double bond migration. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：16 / 22

页数：7

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