Evaluation of systemic absorption and renal effects of topical ophthalmic flurbiprofen and diclofenac in healthy cats

被引:7
|
作者
Lanuza, Rick [1 ]
Rankin, Amy J. [1 ]
KuKanich, Butch [2 ]
Meekins, Jessica M. [1 ]
机构
[1] Kansas State Univ, Dept Clin Sci, Manhattan, KS 66506 USA
[2] Kansas State Univ, Dept Anat & Physiol, Manhattan, KS 66506 USA
关键词
diclofenac; feline; flurbiprofen; nonsteroidal anti-inflammatory; renal; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PREDNISOLONE ACETATE; HEPATIC-FUNCTION; ADRENAL-GLAND; AGED CATS; DOGS; CARBOXYLESTERASE; GLUCURONIDATION; MELOXICAM; EXCRETION;
D O I
10.1111/vop.12295
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Objective To investigate systemic absorption and renal effects of topically applied ophthalmic flurbiprofen and diclofenac in healthy cats. Animals studied Twelve domestic shorthair cats. Procedures Cats were randomly assigned to two treatment groups (n = 6) and administered one drop (approximately 40 lL) of either flurbiprofen 0.03% or diclofenac 0.1% in both eyes four times daily (6 am, 12 pm, 6 pm, and 12 am) for 14 days. Blood samples were collected on days 0, 4, 8, 14, 16, and 17 and analyzed by liquid chromatography and mass spectrometry for flurbiprofen and diclofenac plasma concentrations. A complete blood count (CBC), serum chemistry, and urinalysis were analyzed at the beginning of the study (Day 0) and at the end of topical drug administration (Day 15). Results Both drugs demonstrated systemic absorption. Flurbiprofen was detected (mean +/- SD) at day 4 (237 +/- 65 ng/mL), day 8 (396 +/- 91 ng/mL), day 14 (423 +/- 56 ng/mL), day 16 (350 +/- 66 ng/mL), and day 17 (270 +/- 62 ng/mL), and diclofenac was detected (mean +/- SD) at day 4 (130 +/- 44 ng/mL), day 8 (131 +/- 25 ng/mL), day 14 (150 +/- 36 mg/mL), and sporadically on day 16. Flurbiprofen plasma concentration decreased slowly over 48 h after the last dose. No clinically significant abnormalities were noted in the serum blood urea nitrogen, creatinine, or urine specific gravity at the end of topical drug administration compared to the beginning of the study. Conclusions Flurbiprofen and diclofenac were systemically absorbed after topical administration four times daily to both eyes of healthy cats. Flurbiprofen reached higher plasma concentrations compared to diclofenac.
引用
收藏
页码:24 / 29
页数:6
相关论文
共 50 条
  • [31] ASSESSMENT OF SYSTEMIC EFFECTS OF DIFFERENT OPHTHALMIC BETA-BLOCKERS IN HEALTHY-VOLUNTEERS
    BAUER, K
    BRUNNERFERBER, F
    DISTLERATH, LM
    LIPPA, EA
    BINKOWITZ, B
    TILL, P
    KAIK, G
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1991, 49 (06) : 658 - 664
  • [32] Diclofenac systemic bioavailability of a topical 1% diclofenac+3% menthol combination gel vs. an oral diclofenac tablet in healthy volunteers: a randomized, open-label, crossover study
    Moreira, Sebastian A.
    Liu, D. Jeffery
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2017, 55 (04) : 368 - 372
  • [33] Effects of Atorvastatin on Systemic and Renal Nitric Oxide in Healthy Man
    Mose, Frank Holden
    Larsen, Thomas
    Bech, Jesper Noergaard
    Pedersen, Erling Bjerregaard
    CLINICAL AND EXPERIMENTAL HYPERTENSION, 2013, 35 (02) : 148 - 157
  • [34] The effects of a unilateral ultrasound-guided renal biopsy on renal function in healthy sedated cats
    Drost, WT
    Henry, GA
    Meinkoth, JH
    Woods, JP
    Payton, ME
    Rodebush, C
    VETERINARY RADIOLOGY & ULTRASOUND, 2000, 41 (01) : 57 - 62
  • [35] Evaluation of the effects of topical ophthalmic fluoroquinolones (FQ) on the cornea using in vivo confocal microscopy
    Kim, AS
    McCulley, JP
    Cavanagh, HD
    Jester, JV
    Bugde, AC
    Kovoor, T
    Petroll, WM
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 : U324 - U324
  • [36] Efficiency of topical and systemic flurbiprofen on pain and edema after impacted third molar surgery and comparison of gastrointestinal adverse effects
    Cebi, Ahmet Taylan
    CUKUROVA MEDICAL JOURNAL, 2020, 45 (01): : 141 - 147
  • [37] Evaluation of the effects of nephrotomy on renal function in clinically normal cats
    Bolliger, C
    Walshaw, R
    Kruger, JM
    Rosenstein, DS
    Richter, MA
    Hauptman, JG
    Mauer, WA
    AMERICAN JOURNAL OF VETERINARY RESEARCH, 2005, 66 (08) : 1400 - 1407
  • [38] EFFECTS OF SYSTEMIC AND TOPICAL ADMINISTRATION OF METOPROLOL ON INTRAOCULAR-PRESSURE IN HEALTHY-SUBJECTS
    ALM, A
    WICKSTROM, CP
    ACTA OPHTHALMOLOGICA, 1980, 58 (05): : 740 - 747
  • [39] Effects of 0.5% Timolol Maleate Ophthalmic Solution on Heart Rate and Selected Echocardiographic Indices in Apparently Healthy Cats
    Gunther-Harrington, C. T.
    Ontiveros, E. S.
    Hodge, T. E.
    Visser, L. C.
    Stern, J. A.
    JOURNAL OF VETERINARY INTERNAL MEDICINE, 2016, 30 (03) : 733 - 740
  • [40] EVALUATION OF THE SYSTEMIC ABSORPTION AND EXCRETION OF INTRANASAL IPRATROPIUM BROMIDE IN HEALTHY-VOLUNTEERS
    MACGREGOR, TR
    WOOD, CC
    SHRAGIS, ED
    ROSZKO, PJ
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1992, 89 (01) : 182 - 182