Copper-Catalyzed Direct Trifluoromethylthiolation of Benzylic C-H Bonds via Nondirected Oxidative C(sp3)-H Activation

被引：142
|
作者：
Chen, Chao [1 ]
Xu, Xiu-Hua [1 ]
Yang, Bin [1 ]
Qing, Feng-Ling [1 ,2 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 12期
基金：
中国国家自然科学基金;
关键词：
HYPERVALENT IODINE REAGENT; ALPHA-FLUORINATED ETHERS; ARYL BORONIC ACIDS; METAL-FREE; ELECTROPHILIC TRIFLUOROMETHANESULFANYLATION; ENANTIOSELECTIVE TRIFLUOROMETHYLTHIOLATION; NUCLEOPHILIC TRIFLUOROMETHYLTHIOLATION; AMINATION; MILD; GENERATION;
D O I：
10.1021/ol501400u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed trifluoromethylthiolation of benzylic sp(3) C-H bonds was developed via nondirected oxidative C-H activation using readily prepared and stable AgSCF3. This reaction provides a novel and straightforward method for the preparation of various benzyl trifluoromethyl sulfides.
引用
收藏
页码：3372 / 3375
页数：4
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