SYNTHESIS OF NEW PIROXICAM DERIVATIVES AND THEIR INFLUENCE ON LIPID BILAYERS

被引：0

作者：

Szczesniak-Siega, Berenika ^{[1
]}

Maniewska, Jadwiga ^{[1
]}

Pola, Andrzej ^{[2
]}

Sroda-Pomianek, Kamila ^{[2
]}

Malinka, Wieslaw ^{[1
]}

Michalak, Krystyna ^{[2
]}

机构：

[1] Wroclaw Med Univ, Dept Chem Drugs, Borowska 211, PL-50556 Wroclaw, Poland

[2] Wroclaw Med Univ, Dept Biophys, PL-50368 Wroclaw, Poland

来源：

ACTA POLONIAE PHARMACEUTICA | 2014年 / 71卷 / 06期

关键词：

synthesis; piroxicam; lipid bilayers; fluorescence spectroscopy; multitarget drugs; beneothiazines; MDR;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A novel series of potentially biologically active 1,2-benzothiazine 1,1-dioxides - analogs of piroxicam (a recognized non-steroidal anti-inflammatory drug) were synthesized from commercially available saccharin. All of the synthesized compounds were subjected to preliminary evaluation for their ability to interact with lipid bilayers. The influence of the new derivatives of piroxicam on liposomes made of EYPC was investigated by fluorescence spectroscopy with two fluorescent probes - Laurdan and Prodan. All the studied compounds showed an interaction with model membranes.

引用

页码：1045 / 1050

页数：6

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