SYNTHESIS OF NEW PIROXICAM DERIVATIVES AND THEIR INFLUENCE ON LIPID BILAYERS

被引：0
|
作者：
Szczesniak-Siega, Berenika [1 ]
Maniewska, Jadwiga [1 ]
Pola, Andrzej [2 ]
Sroda-Pomianek, Kamila [2 ]
Malinka, Wieslaw [1 ]
Michalak, Krystyna [2 ]
机构：
[1] Wroclaw Med Univ, Dept Chem Drugs, Borowska 211, PL-50556 Wroclaw, Poland
[2] Wroclaw Med Univ, Dept Biophys, PL-50368 Wroclaw, Poland
来源：
ACTA POLONIAE PHARMACEUTICA | 2014年 / 71卷 / 06期
关键词：
synthesis; piroxicam; lipid bilayers; fluorescence spectroscopy; multitarget drugs; beneothiazines; MDR;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A novel series of potentially biologically active 1,2-benzothiazine 1,1-dioxides - analogs of piroxicam (a recognized non-steroidal anti-inflammatory drug) were synthesized from commercially available saccharin. All of the synthesized compounds were subjected to preliminary evaluation for their ability to interact with lipid bilayers. The influence of the new derivatives of piroxicam on liposomes made of EYPC was investigated by fluorescence spectroscopy with two fluorescent probes - Laurdan and Prodan. All the studied compounds showed an interaction with model membranes.
引用
收藏
页码：1045 / 1050
页数：6
相关论文
共 50 条
  • [1] THE INTERACTION OF NEW PIROXICAM ANALOGUES WITH LIPID BILAYERS - A CALORIMETRIC AND FLUORESCENCE SPECTROSCOPIC STUDY
    Maniewska, Jadwiga
    Szczesniak-Siega, Berenika
    Pola, Andrzej
    Sroda-Pomianek, Kamila
    Malinka, Wieslaw
    Michalak, Krystyna
    ACTA POLONIAE PHARMACEUTICA, 2014, 71 (06): : 1004 - 1012
  • [2] The interaction of new oxicam derivatives with lipid bilayers as measured by calorimetry and fluorescence spectroscopy
    Maniewska, Jadwiga
    Gasiorowska, Justyna
    Szczesniak-Siega, Berenika
    Michalak, Krystyna
    ACTA BIOCHIMICA POLONICA, 2018, 65 (02) : 185 - 191
  • [3] MODE OF INSERTION OF IMIDAZOLE DERIVATIVES IN LIPID BILAYERS
    BRASSEUR, R
    VANDENBOSCH, C
    MARICHAL, P
    VANDENBOSSCHE, H
    ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE, 1982, 90 (02): : BP20 - BP21
  • [4] Pyridinium Salts Influence on Lipid Bilayers
    Funari, Sergio S.
    Di Vitta, Claudio
    Marzorati, Liliana
    BIOPHYSICAL JOURNAL, 2014, 106 (02) : 90A - 90A
  • [5] Influence of pyridinium salts on lipid bilayers
    Funari, S. S.
    Di Vitta, C.
    Marzorati, L.
    Luchese, A. M.
    Yamaoka, P.
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2015, 44 : S191 - S191
  • [6] Influence of resveratrol on properties of lipid bilayers
    不详
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2005, 34 (06): : 690 - 690
  • [7] Chitosan derivatives targeting lipid bilayers: Synthesis, biological activity and interaction with model membranes
    Martins, Danubia Batista
    Nasário, Fábio Domingues
    Silva-Gonçalves, Laiz Costa
    de Oliveira Tiera, Vera Aparecida
    Arcisio-Miranda, Manoel
    Tiera, Marcio José
    dos Santos Cabrera, Marcia Perez
    Carbohydrate Polymers, 2018, 181 : 1213 - 1223
  • [8] Chitosan derivatives targeting lipid bilayers: Synthesis, biological activity and interaction with model membranes
    Martins, Danubia Batista
    Nasario, Fabio Domingues
    Silva-Goncalves, Laiz Costa
    de Oliveira Tiera, Vera Aparecida
    Arcisio-Miranda, Manoel
    Tiera, Marcio Jose
    dos Santos Cabrera, Marcia Perez
    CARBOHYDRATE POLYMERS, 2018, 181 : 1213 - 1223
  • [9] Chitosan derivatives targeting lipid bilayers: Synthesis, biological activity and interaction with model membranes
    Martins, Danubia Batista
    Nasário, Fábio Domingues
    Silva-Gonçalves, Laiz Costa
    de Oliveira Tiera, Vera Aparecida
    Arcisio-Miranda, Manoel
    Tiera, Marcio José
    dos Santos Cabrera, Marcia Perez
    Carbohydrate Polymers, 2018, 181 : 1213 - 1223
  • [10] Thermodynamics of New Piroxicam Derivatives in Terahertz Light
    Szczesniak-Siega, B.
    Fuglewicz, B.
    Nowak, K.
    Szlachetko, B.
    Sterczewski, L. A.
    Beziuk, G.
    Jarzab, P. P.
    Malinka, W.
    Baran, J.
    Drozd, M.
    Grzelczak, M. P.
    Hruszowiec, M.
    Plinska, S.
    Plinski, E. F.
    2014 39TH INTERNATIONAL CONFERENCE ON INFRARED, MILLIMETER, AND TERAHERTZ WAVES (IRMMW-THZ), 2014,
12345