Thiol-ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors

被引：12

作者：

Saada, Mohamed-Chiheb ^{[1
]}

Ombouma, Joanna ^{[1
]}

Montero, Jean-Louis ^{[1
]}

Supuran, Claudiu T. ^{[2
]}

Winum, Jean-Yves ^{[1
]}

机构：

[1] Ecole Natl Super Chim Montpellier, IBMM, UMR 5247, CNRS UM1 UM2, F-34296 Montpellier, France

[2] Univ Florence, Neurofarba Dept, Sect Pharmaceut Sci, I-50019 Florence, Italy

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 50期

关键词：

BENZENE SULFONAMIDES; THERAPEUTIC APPLICATIONS; ISOFORM-IX; ISOZYME-IX; XII; MOIETIES; CANCER; AGENTS;

D O I：

10.1039/c3cc42541j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Thiol-ene click chemistry has been applied for obtaining sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors incorporating sugar moieties. Most of these new compounds were moderate CA I inhibitors, effective CA II inhibitors, and low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms CA IX and XII.

引用

页码：5699 / 5701

页数：3

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