Neuroinflammatory pathways in anxiety, posttraumatic stress, and obsessive compulsive disorders

被引：125

作者：

Furtado, Melissa ^{[1
]}

Katzman, Martin A. ^{[1
,2
,3
,4
,5
]}

机构：

[1] START Clin Mood & Anxiety Disorders, Toronto, ON M4W 2N4, Canada

[2] Univ Toronto, Fac Med, Dept Psychiat, Toronto, ON M5S 1A1, Canada

[3] Northern Ontario Sch Med, Thunder Bay, ON, Canada

[4] Lakehead Univ, Dept Psychol, Thunder Bay, ON P7B 5E1, Canada

[5] Adler Grad Profess Sch, Toronto, ON, Canada

来源：

PSYCHIATRY RESEARCH | 2015年 / 229卷 / 1-2期

关键词：

Generalized anxiety disorder; Social anxiety disorder; Panic disorder; Posttraumatic stress disorder; Obsessive compulsive disorder; Inflammation; Hypothalamic pituitary adrenal axis; C-REACTIVE PROTEIN; PITUITARY-ADRENAL ACTIVITY; TUMOR-NECROSIS-FACTOR; GENERALIZED ANXIETY; SALIVARY CORTISOL; HAIR CORTISOL; TNF-ALPHA; HPA AXIS; DEPRESSIVE SYMPTOMS; PHYSICAL DISORDERS;

D O I：

10.1016/j.psychres.2015.05.036

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

As prevalence of anxiety, posttraumatic stress, and obsessive compulsive disorders continue to rise worldwide, increasing focus has been placed on immune mediated theories in understanding the underlying mechanisms of these disorders. Associations between the dysregulation of the hypothalamic pituitary adrenal (HPA) axis and these disorders have been recognized in the scientific literature, specifically in regard to cortisol levels, as well as changes in pro- and anti-inflammatory cytokines. The present commentary will systematically assess the scientific literature within the past decade in regard to the psychoneuroimmunology of anxiety, posttraumatic stress, and obsessive compulsive disorders. Understanding the mechanisms of these disorders is essential in order to determine efficacious and targeted treatment strategies, which may lead to substantial improvements in overall functioning, as well as significant decreases in societal and economic burden. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：37 / 48

页数：12

共 50 条

[21] Motor semiology in anxiety and obsessive-compulsive disorders
Fovet, Thomas
Hernout, Julien
Pelissolo, Antoine
ANNALES MEDICO-PSYCHOLOGIQUES, 2017, 175 (05): : 469 - 473
[22] Anxiety disorders and the family: the obsessive compulsive disorder as a model
Riquier, F
MEDECINE ET HYGIENE, 2004, 62 (2496): : 1781 - 1785
[23] Current Treatments for Anxiety and Obsessive-Compulsive Disorders
Sayed S.
Horn S.R.
Murrough J.W.
Current Treatment Options in Psychiatry, 2014, 1 (3) : 248 - 262
[24] An update on the pharmacology of anxiolytics for the anxiety, obsessive compulsive and post-traumatic stress disorders
Outhoff, Kim
SA PHARMACEUTICAL JOURNAL, 2016, 83 (05) : 21 - 26
[25] Memory bias in obsessive-compulsive and anxiety disorders
Edalatzadeh, Nasrin
Kabirnezhad, Sanaz
Alilo, Majid Mahmud
2ND WORLD CONFERENCE ON PSYCHOLOGY, COUNSELLING AND GUIDANCE-2011, 2011, 30
[26] The Stress of Caring for People with Obsessive Compulsive Disorders
Tannis M. Laidlaw
Ian R.H. Falloon
Denise Barnfather
John H. Coverdale
Community Mental Health Journal, 1999, 35 : 443 - 450
[27] The stress of caring for people with obsessive compulsive disorders
Laidlaw, TM
Falloon, IRH
Barnfather, D
Coverdale, JH
COMMUNITY MENTAL HEALTH JOURNAL, 1999, 35 (05) : 443 - 450
[28] The Place of Antipsychotics in the Therapy of Anxiety Disorders and Obsessive-Compulsive Disorders
Baptiste Pignon
Chloé Tezenas du Montcel
Louise Carton
Antoine Pelissolo
Current Psychiatry Reports, 2017, 19
[29] The Place of Antipsychotics in the Therapy of Anxiety Disorders and Obsessive-Compulsive Disorders
Pignon, Baptiste
du Montcel, Chloe Tezenas
Carton, Louise
Pelissolo, Antoine
CURRENT PSYCHIATRY REPORTS, 2017, 19 (12)
[30] Neurostimulation in Anxiety Disorders, Post-traumatic Stress Disorder, and Obsessive-Compulsive Disorder
Freire, Rafael Christophe
Cabrera-Abreu, Casimiro
Milev, Roumen
ANXIETY DISORDERS: RETHINKING AND UNDERSTANDING RECENT DISCOVERIES, 2020, 1191 : 331 - 346

← 1 2 3 4 5 →