Nitric oxide-dependent suppression of flavin-containing monooxygenase expression in rat liver

被引：0

作者：

Park, CS ^{[1
]}

Baek, HM ^{[1
]}

Chung, WG ^{[1
]}

Lee, KH ^{[1
]}

Ryu, SD ^{[1
]}

Cha, YN ^{[1
]}

机构：

[1] Inha Univ, Coll Med, Dept Pharmacol & Toxicol, Inchon 402751, South Korea

来源：

BIOLOGY OF NITRIC OXIDE, PT 7 | 2000年 / 16卷

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Liver microsomal FMO activities of LPS-treated rats were decreased significantly. Hepatic content of FMO1 mRNA and tile liver microsomal content of FMO I (the major form in rat liver) in LPS-treated rats were significantly decreased also, However. the expression of inducible NO synthase (iNOS) and plasma nitrate/nitrite (NOx) concentration were increased. In rats cotreated with NOS inhibitors such as aminoguanidine and nitro L-arginine. the ativities and content of FMO1 in liver microsomes were restored. These results suggest that NO is an important mediator involved in the suppression of FMO1 activity in vivo.

引用

页码：123 / 123

页数：1

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