Necrotizing sarcoid granulomatosis

被引:26
|
作者
Yeboah, John [1 ]
Afkhami, Michelle [1 ]
Lee, Christopher [1 ]
Sharma, Om P. [1 ]
机构
[1] Univ So Calif, Keck Sch Med, Div Pulm & Crit Care Med, Los Angeles, CA 90033 USA
关键词
necrotizing; nodular lung disease; sarcoid; vasculitis; Wegener's granulomatosis; INVOLVEMENT;
D O I
10.1097/MCP.0b013e3283560824
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Purpose of review Necrotizing sarcoid granulomatosis (NSG) is rare. Its various clinical and histological presentations are ambiguous and confusing. Although sometimes limited only to the lungs, other organ systems can be involved. The disease affects primarily women in their late forties but has been documented in children. Recent findings There are two schools of thought regarding the taxonomical position of NSG. Some believe that it is an independent entity, whereas others argue that it is just another manifestation of sarcoidosis. This article will review the available, current and evidence-based information about clinical and basic science aspects of NSG. Summary Diagnosis of NSG is perplexing; its pathogenesis is a dilemma. The disease is frequently confused with other processes including malignancy, Wegener's granulomatosis, hypersensitivity pneumonitis, sarcoidosis and lymphoid granulomatosis. Its symptoms are nonspecific and a histology finding of necrotizing granuloma has many causes. Although no specific management tool or strategies are advocated, steroids, surgical resection of localized disease or sometimes watchful waiting are recommended.
引用
收藏
页码:493 / 498
页数:6
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