Stereoselective strategy for the synthesis of (+)-polyoxamic acid and some polyhydroxylated pyrrolidines

被引：6

作者：

Lingamurthy, Macha ^{[1
]}

Rajender, Anugula ^{[1
]}

Rao, Batchu Venkateswara ^{[1
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Organ & Biomol Chem Div, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 46期

关键词：

Polyoxamic acid; Iminosugars; Glycosidase inhibitors; Stereoselective; Grignard reaction; POLYOXAMIC ACID; CONVENIENT SYNTHESIS; GLYCOSIDASE INHIBITORS; ASYMMETRIC-SYNTHESIS; ANTIMITE SUBSTANCE; NATURAL OCCURRENCE; SPHINGOFUNGIN-C; AMINO-ACIDS; DERIVATIVES; EFFICIENT;

D O I：

10.1016/j.tetlet.2013.08.126

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient strategy for the synthesis of dihydroxy chiral amino moiety which can be utilized for the synthesis of polyoxamic acid, 1,4-dideoxy-1,4-imino-D-xylitol, and dihydroxy pyrrolidine by using highly diastereoselective nucleophilic addition on chiral imine has been reported. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：6189 / 6191

页数：3

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