Photoredox-Catalyzed Trifluoromethylative Intramolecular Cyclization: Synthesis of CF3-Containing Heterocyclic Compounds

被引：30
|
作者：
Han, Hong Sik [1 ,2 ]
Oh, Eun Hye [2 ,3 ]
Jung, Young-Sik [1 ,2 ]
Han, Soo Bong [1 ,2 ]
机构：
[1] Univ Sci & Technol, Dept Med & Pharmaceut Chem, 217 Gajeongro, Yuseong 34113, Daejeon, South Korea
[2] Korea Res Inst Chem Technol, Div Bio & Drug Discovery, 141 Gajeongro, Yuseong 34114, Daejeon, South Korea
[3] Korea Univ, Dept Chem, 145 Anam Ro, Seoul 02841, South Korea
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 07期
关键词：
ASYMMETRIC HYDROGENATION; FACILE ACCESS; LIGHT; DERIVATIVES; ALKYNES; DESIGN; HETEROARENES; CONSTRUCT; FLUORINE;
D O I：
10.1021/acs.orglett.8b00648
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general photoredox-catalyzed intramolecular cyclization was developed for the synthesis of trifluoromethylated heterocydic compounds. The reaction proceeded smoothly under mild photocatalytic conditions with high functional group tolerance, allowing the preparation of oxygen-, sulfur-, or nitrogen-containing heterocycles of different sizes. The broad.,substrate scope demonstrated the complexity-building potential of the strategy.
引用
收藏
页码：1698 / 1702
页数：5
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