The period covered by this review has seen exciting developments in our understanding of Down's syndrome. Of particular interest has been further elucidation of the clinical features of dementia, through the use of longitudinal, rather than cross-sectional, methodologies. Recent findings relating to apolipoprotein-E and other factors suggest that the relationship between Down's syndrome and dementia may be rather more complex than previously thought. Curr Opin Psychiatry 12:567-571. (C) 1999 Lippincott Williams & Wilkins.
机构:
Hosp Univ Sains Malaysia, Sch Med Sci, Dept Pediat, Kelantan 16150, MalaysiaHosp Univ Sains Malaysia, Sch Med Sci, Dept Pediat, Kelantan 16150, Malaysia
机构:
Employees State Insurance Corp Hosp, Dept Paediat, Kolkata, W Bengal, IndiaEmployees State Insurance Corp Hosp, Dept Paediat, Kolkata, W Bengal, India
Banerjee, Pritam
Thapa, Rajoo
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机构:Employees State Insurance Corp Hosp, Dept Paediat, Kolkata, W Bengal, India