Anatomical aspects, chemical analysis and cytotoxic effect of the essential oil from leaves of Casearia arborea (Salicaceae)

被引：0
|
作者：
Pereira, Flaviane Gomes [1 ]
Marquete, Ronaldo [2 ]
Leite, Kosme Oliveira [3 ]
Cabral, Otavio Versiane [3 ]
May, Barrie [4 ]
Mansur, Elisabeth [5 ]
Moreira, Davyson de Lima [6 ]
机构：
[1] Univ Fed Rio de Janeiro, Programa Posgrad Biotecnol Vegetal & Bioproc, BR-21941 Rio De Janeiro, Brazil
[2] Coordenadoria Recursos Nat CREN, Diretoria Geociencias, IBGE, Rio De Janeiro, Brazil
[3] Inst Fed Educ Ciencia & Tecnol Rio de Janeiro IFR, Rio De Janeiro, Brazil
[4] TreeMod Co, Glen Waverley, Vic 3150, Australia
[5] Univ Estado Rio de Janeiro UERJ, Dept Biol, Rio De Janeiro, Brazil
[6] Fundacao Oswado Cruz Fiocruz, Dept Nat Prod, Inst Tecnol Farmacos, Rio De Janeiro, Brazil
来源：
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS | 2017年 / 16卷 / 02期
关键词：
A549; byciclogermacrene; Casearia arborea; salicaceae; secretory cavities; sesquiterpene; SYLVESTRIS; ANTIOXIDANT; DITERPENES;
D O I：
暂无
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
The genus Casearia (Salicaceae) is found in sub-tropical and tropical regions of the world and comprises about 200 species. In Brazil, there are about 48 species and 12 are registered in the State of Rio de Janeiro; including Casearia arborea (Rich.) Urb. Essential oil was obtained from the fresh leaves by hydrodistillation and analyzed by GC-MS and GC-FID. The cytotoxic effect was determined by WST-1 assay. Chemical analysis of the essential oil revealed a very diversified (n = 37 compounds) volatile fraction composed mainly of non-oxygenated sesquiterpenes (90.2%). These sesquiterpenes included byciclogermacrene (18.7%), germacrene D (12.1%) and alpha-humulene (11.5%). In addition, the essential oil demonstrated cytotoxic effects against A549 tumor cells in the concentration of 4 mu g/mL (EC50) (p < 0.05).
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页码：99 / 109
页数：11
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