Additional Genetic Risk Factor for Death in Children With Acute Lymphoblastic Leukemia: A Common Polymorphism of the MTHFR Gene

被引：17

作者：

Pietrzyk, Jacek J. ^{[1
]}

Bik-Multanowski, Miroslaw ^{[1
]}

Balwierz, Walentyna ^{[2
]}

Skoczen, Szymon ^{[2
]}

Wojcik, Dorota ^{[3
]}

Chybicka, Alicja ^{[3
]}

Sikorska-Fic, Barbara ^{[4
]}

Matysiak, Michal ^{[4
]}

Szczepanski, Tomasz ^{[5
]}

Sonta-Jakimczyk, Danuta ^{[5
]}

Ploszynska, Anna ^{[6
]}

Balcerska, Anna ^{[6
]}

Mycko, Katarzyna ^{[7
]}

Bodalski, Jerzy ^{[7
]}

Krawczuk-Rybak, Maryna ^{[8
]}

Kowalczyk, Jerzy ^{[9
]}

Koltan, Andrzej ^{[10
]}

Sobol, Grazyna ^{[11
]}

Derwich, Katarzyna ^{[12
]}

Kwinta, Przemko ^{[1
]}

机构：

[1] Jagiellonian Univ, Chair Pediat, PL-30663 Krakow, Poland

[2] Jagiellonian Univ, Dept Childrens Oncol & Hematol, PL-30663 Krakow, Poland

[3] Wroclaw Med Univ, Dept Pediat Bone Marrow Transplantat Oncol & Hema, Wroclaw, Poland

[4] Med Univ, Dept Pediat Hematol & Oncol, Warsaw, Poland

[5] Silesian Acad Med, Dept Pediat Hematol & Oncol, Zabrze, Poland

[6] Med Univ, Dept Childrens Oncol & Hematol, Gdansk, Poland

[7] Med Univ, Dept Pediat, Lodz, Poland

[8] Med Univ, Dept Childrens Oncol, Bialystok, Poland

[9] Med Univ, Dept Childrens Hematol & Oncol, Lublin, Poland

[10] Univ Coll Med, Dept Pediat Oncol & Hematol, Bydgoszcz, Poland

[11] Med Univ Silesia, Dept Pediat, Oncol Hematol & Chemotherapy Unit, Katowice, Poland

[12] Univ Med Sci, Dept Pediat Oncol Hematol & Transplantol, Poznan, Poland

来源：

PEDIATRIC BLOOD & CANCER | 2009年 / 52卷 / 03期

关键词：

DNA methylation; drug metabolism; homocysteine; mortality; pharmacogenetics; METHYLENETETRAHYDROFOLATE REDUCTASE; THYMIDYLATE SYNTHASE; CHILDHOOD; PHARMACOGENETICS; SUSCEPTIBILITY; MUTATION; THERAPY; DISEASE;

D O I：

10.1002/pbc.21815

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background The presence of metabolically important genetic polymorphisms may affect treatment efficacy in patients with malignancies. The objective of this prospective multicenter study Was to evaluate the role of selected polymorphisms of genes associated with metabolism of chemotherapeutic drugs as prognostic markers in children with acute lymphoblastic leukemia. Procedure. Genotyping for the presence of 7 genetic variants in 403 patients and analysis of death cases were performed. Results. Thirty-one children died before reaching remission maintenance phase. Genetic analysis revealed in this group increased frequency of homozygosity for c.677C>T polymorphism of the MTHFR gene (26% vs. 8% in the survivors; OR 4,09; 95% CI 1.67-10; adjusted for multiple testing P=0.028). Conclusion. Our data Suggest that modification of anti-leukemic treatment should be considered in patients homozygous for c.677C>T polymorphism. Pediatr Blood Cancer 2009;52:364-368 (C) 2008 Wiley-Liss, Inc.

引用

页码：364 / 368

页数：5

共 50 条

[21] Impact of ABO gene polymorphism and von Willebrand factor on genetic susceptibility to acute lymphoblastic leukemia in Egyptian pediatric patients
Salim, Elsayed I.
Shaaban, Ahmed N.
Seleem, Amal K.
Attia, Zeinab I.
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS, 2025, 26 (01)
[22] Genetic variation and the risk of acute lymphoblastic leukemia
Mullighan, Charles G.
LEUKEMIA RESEARCH, 2010, 34 (10) : 1269 - 1270
[23] MYBL2 Gene Polymorphism Is Associated With Acute Lymphoblastic Leukemia Susceptibility in Children
Guo, Haixia
Li, Na
Sun, Yaping
Wu, Cuiling
Deng, Huixia
Xu, Ling
Yang, Xu
FRONTIERS IN ONCOLOGY, 2021, 11
[24] MTHFR genetic polymorphism and the risk of intrauterine fetal death in Polish women
Wolski, Hubert
Kurzawinska, Grazyna
Drews, Krzysztof
Barlik, Magdalena
Kadziolka, Przemyslaw
Malewski, Zbyszko
Mikolajska-Ptas, Paula
Bylewski, Michal
Seremak-Mrozikiewicz, Agnieszka
GINEKOLOGIA POLSKA, 2019, 90 (02) : 76 - 81
[25] RFC1 AND MTHFR GENES POLYMORPHISMS AND RISK OF PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA WITH COMMON ACQUIRED ALTERATIONS
Emerenciano, Mariana
Faro, Alessandra de Jesus
de Aguiar Goncalves, Bruno Alves
Zanrosso, Crisiane Wais
Andrade, Camilla
Cartaxo Muniz, Maria Tereza
Pombo-de-Oliveira, Maria Socorro
PEDIATRIC BLOOD & CANCER, 2010, 55 (05) : 849 - 850
[26] The influence of MTHFR genetic polymorphisms on methotrexate therapy in pediatric acute lymphoblastic leukemia
Shen, Yaqing
Wang, Zhujun
Zhou, Fen
Jin, Runming
OPEN LIFE SCIENCES, 2021, 16 (01): : 1203 - 1212
[27] MTHFR C677T Polymorphism Screening: A Challenge in Acute Lymphoblastic Leukemia
Frikha, Rim
Rebai, Tarek
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2017, 17 : S269 - S269
[28] Genetic polymorphisms in the cytochrome gene family and the risk of childhood acute lymphoblastic leukemia
Scelo, G.
Chokkalingam, A. P.
Metayer, C.
Guha, N.
Barcellos, L. F.
Wiemels, J. L.
Wiencke, J. K.
Buffler, P. A.
EJC SUPPLEMENTS, 2008, 6 (09): : 207 - 207
[29] Induction Death of Children with Acute Lymphoblastic Leukemia in Japan
Nakagawa, Shunsuke
Okamoto, Yasuhiro
Imamura, Toshihiko
Imai, Chihaya
Kato, Motohiro
Kawano, Yoshifumi
Shimomura, Yasuto
Watanabe, Arata
Kikuta, Atsushi
Saito, Akiko
Horibe, Keizo
Manabe, Atsushi
Ohara, Akira
Koh, Katsuyoshi
PEDIATRIC BLOOD & CANCER, 2018, 65 : S16 - S16
[30] EVALUATION OF DEATH AT HOME FOR CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
FORTUNATO, RP
KOMP, DM
CLINICAL RESEARCH, 1977, 25 (01): : A74 - A74

← 1 2 3 4 5 →