Additional Genetic Risk Factor for Death in Children With Acute Lymphoblastic Leukemia: A Common Polymorphism of the MTHFR Gene

被引：17

作者：

Pietrzyk, Jacek J. ^{[1
]}

Bik-Multanowski, Miroslaw ^{[1
]}

Balwierz, Walentyna ^{[2
]}

Skoczen, Szymon ^{[2
]}

Wojcik, Dorota ^{[3
]}

Chybicka, Alicja ^{[3
]}

Sikorska-Fic, Barbara ^{[4
]}

Matysiak, Michal ^{[4
]}

Szczepanski, Tomasz ^{[5
]}

Sonta-Jakimczyk, Danuta ^{[5
]}

Ploszynska, Anna ^{[6
]}

Balcerska, Anna ^{[6
]}

Mycko, Katarzyna ^{[7
]}

Bodalski, Jerzy ^{[7
]}

Krawczuk-Rybak, Maryna ^{[8
]}

Kowalczyk, Jerzy ^{[9
]}

Koltan, Andrzej ^{[10
]}

Sobol, Grazyna ^{[11
]}

Derwich, Katarzyna ^{[12
]}

Kwinta, Przemko ^{[1
]}

机构：

[1] Jagiellonian Univ, Chair Pediat, PL-30663 Krakow, Poland

[2] Jagiellonian Univ, Dept Childrens Oncol & Hematol, PL-30663 Krakow, Poland

[3] Wroclaw Med Univ, Dept Pediat Bone Marrow Transplantat Oncol & Hema, Wroclaw, Poland

[4] Med Univ, Dept Pediat Hematol & Oncol, Warsaw, Poland

[5] Silesian Acad Med, Dept Pediat Hematol & Oncol, Zabrze, Poland

[6] Med Univ, Dept Childrens Oncol & Hematol, Gdansk, Poland

[7] Med Univ, Dept Pediat, Lodz, Poland

[8] Med Univ, Dept Childrens Oncol, Bialystok, Poland

[9] Med Univ, Dept Childrens Hematol & Oncol, Lublin, Poland

[10] Univ Coll Med, Dept Pediat Oncol & Hematol, Bydgoszcz, Poland

[11] Med Univ Silesia, Dept Pediat, Oncol Hematol & Chemotherapy Unit, Katowice, Poland

[12] Univ Med Sci, Dept Pediat Oncol Hematol & Transplantol, Poznan, Poland

来源：

PEDIATRIC BLOOD & CANCER | 2009年 / 52卷 / 03期

关键词：

DNA methylation; drug metabolism; homocysteine; mortality; pharmacogenetics; METHYLENETETRAHYDROFOLATE REDUCTASE; THYMIDYLATE SYNTHASE; CHILDHOOD; PHARMACOGENETICS; SUSCEPTIBILITY; MUTATION; THERAPY; DISEASE;

D O I：

10.1002/pbc.21815

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background The presence of metabolically important genetic polymorphisms may affect treatment efficacy in patients with malignancies. The objective of this prospective multicenter study Was to evaluate the role of selected polymorphisms of genes associated with metabolism of chemotherapeutic drugs as prognostic markers in children with acute lymphoblastic leukemia. Procedure. Genotyping for the presence of 7 genetic variants in 403 patients and analysis of death cases were performed. Results. Thirty-one children died before reaching remission maintenance phase. Genetic analysis revealed in this group increased frequency of homozygosity for c.677C>T polymorphism of the MTHFR gene (26% vs. 8% in the survivors; OR 4,09; 95% CI 1.67-10; adjusted for multiple testing P=0.028). Conclusion. Our data Suggest that modification of anti-leukemic treatment should be considered in patients homozygous for c.677C>T polymorphism. Pediatr Blood Cancer 2009;52:364-368 (C) 2008 Wiley-Liss, Inc.

引用

页码：364 / 368

页数：5

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