N-H Spin-Spin Couplings: Probing Hydrogen Bonds in Proteins

被引：14

作者：

Xiang, Sheng-Qi ^{[1
]}

Narayanan, Raghavendran L. ^{[1
]}

Becker, Stefan ^{[1
]}

Zweckstetter, Markus ^{[1
,2
]}

机构：

[1] Max Planck Inst Biophys Chem, D-37077 Gottingen, Germany

[2] Deutsch Zentrum Neurodegenerat Erkrankungen DZNE, D-37077 Gottingen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 12期

关键词：

amides; coupling constants; hydrogen bonds; NMR spectroscopy; proteins; SCALAR COUPLINGS; DIPOLAR COUPLINGS; N-15-H-1; SCALAR; CHEMICAL-SHIFTS; CONSTANTS; UBIQUITIN; BINDING; TAU;

D O I：

10.1002/anie.201209641

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sensitive information: Hydrogen bonds stabilize protein structures and are critical for many chemical and biological phenomena. NMR studies found that the one-bond 1H-15N scalar coupling constant is increased by up to 1.6 Hz when a hydrogen bond is formed. These coupling constants therefore provide a sensitive tool for studying protein structure. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3525 / 3528

页数：4

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