Combination of the BCL-2 inhibitor ZN-d5 with the WEE1 inhibitor ZN-c3 shows additive or synergistic anti-tumor activity in acute myeloid leukemia (AML) models

被引：0
|
作者：
Izadi, Hooman [1 ]
Hoang, Tiffany [1 ]
Ibrahim, Noah [1 ]
Pinchman, Joseph [1 ]
Boren, Brant C. [1 ]
Ma, Jianhui [1 ]
de Jong, Petrus R. [1 ]
Li, Jiali [1 ]
Bunker, Kevin D. [1 ]
Samatar, Ahmed A. [1 ]
Donate, Fernando [1 ]
机构：
[1] Zentalis, San Diego, CA USA
来源：
CANCER RESEARCH | 2022年 / 82卷 / 12期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2591
引用
收藏
页数：2
相关论文
共 35 条
  • [31] VS-5584 a dual mTORC1/2 and PI3K inhibitor has anti-tumor activity in multiple in vivo xenograft tumor models and enhanced efficacy in combination with cisplatin or docetaxel
    Trombino, Anthony F.
    Kolev, Vihren N.
    Wright, Quentin G.
    Xu, Qunli
    Padval, Mahesh V.
    CANCER RESEARCH, 2014, 74 (19)
  • [32] FLT3 inhibition by olverembatinib (HQP1351) downregulates MCL-1 and synergizes with BCL-2 inhibitor lisaftoclax (APG-2575) in preclinical models of FLT3-ITD mutant acute myeloid leukemia
    Fang, Douglas D.
    Zhu, Hengrui
    Tang, Qiuqiong
    Wang, Guangfeng
    Min, Ping
    Wang, Qixin
    Li, Na
    Yang, Dajun
    Zhai, Yifan
    TRANSLATIONAL ONCOLOGY, 2022, 15 (01):
  • [33] Combination of the glycoengineered Type II CD20 antibody obinutuzumab (GA101), and the novel Bcl-2 selective inhibitor, ABT-199 (GDC-0199), results in superior in vitro and in vivo anti-tumor activity in models of B-cell malignancies.
    Sampath, Deepak
    Herter, Sylvia
    Ingalla, Ellen
    Herting, Frank
    Bacac, Marina
    Nannini, Michelle
    Fairbrother, Wayne J.
    Klein, Christian
    MOLECULAR CANCER THERAPEUTICS, 2013, 12 (11)
  • [34] Vertical inhibition of the MAPK pathway with D3S-002, a potent and selective ERK1/2 inhibitor, to improve anti-tumor activity of and overcome resistance to KRAS G12C inhibitors
    Zhang, Jing
    Lu, Jingtao
    Zheng, Zhiqiang
    Lu, Jiang
    Wang, Allison
    Wang, Jia
    Chen, Janet
    Rui, Haopeng
    Chen, Cheng
    Chen, Zhi Jian
    CANCER RESEARCH, 2023, 83 (07)
  • [35] Discovery of the Novel Potent and Selective FLT3 Inhibitor 1-{5-[7-(3-Morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and Its Anti-Acute Myeloid Leukemia (AML) Activities in Vitro and in Vivo
    Li, Wei-Wei
    Wang, Xiao-Yan
    Zheng, Ren-Lin
    Yan, Heng-Xiu
    Cao, Zhi-Xing
    Zhong, Lei
    Wang, Ze-Rong
    Ji, Pan
    Yang, Ling-Ling
    Wang, Li-Jiao
    Xu, Yong
    Liu, Jing-Jing
    Yang, Jiao
    Zhang, Chun-Hui
    Ma, Shuang
    Feng, Shan
    Sun, Qi-Zheng
    Wei, Yu-Quan
    Yang, Sheng-Yong
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (08) : 3852 - 3866
1234