IN VITRO TRYPANOCIDAL EVALUATION OF PINANE DERIVATIVES FROM ESSENTIAL OILS OF RIPE FRUITS FROM Schinus terebinthifolius RADDI (ANACARDIACEAE)

被引：0
|
作者：
Sartorelli, Patricia [1 ]
Santana, Jefferson S. [1 ]
Guadagnin, Rafael C. [1 ]
Lago, Joao Henrique G. [1 ]
Pinto, Erika G. [2 ,3 ]
Tempone, Andre G. [2 ]
Stefani, Helio A. [4 ]
Soares, Marisi G. [5 ]
da Silva, Adalberto M. [6 ]
机构：
[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972279 Diadema, SP, Brazil
[2] Adolfo Lutz Inst, Dept Parasitol, BR-01246000 Sao Paulo, Brazil
[3] Univ Sao Paulo, Inst Med Trop Sao Paulo, BR-05403000 Sao Paulo, Brazil
[4] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, BR-05508000 Sao Paulo, Brazil
[5] Univ Fed Alfenas, Inst Quim, BR-37130000 Alfenas, MG, Brazil
[6] Univ Fed Vicosa, Dept Quim, BR-36570000 Vicosa, MG, Brazil
来源：
QUIMICA NOVA | 2012年 / 35卷 / 04期
基金：
巴西圣保罗研究基金会;
关键词：
Schinus terebinthifolius Raddi; Anacardiaceae; trypanocidal activity; CHEMICAL-COMPOSITION; LEAVES; MONOTERPENES;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)-alpha-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 mu g/mL) when compared to benznidazole (IC50 43.14 mu g/mL). Otherwise, (-)-alpha-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 mu g/mL) while (-)-pinane showed an IC50 of 56.50 mu g/mL. The obtained results indicated that the epoxydation of a-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.
引用
收藏
页码：743 / 747
页数：5
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