Metabolic Pathways in Breast Cancer Reprograming: An Insight to Non-Coding RNAs

被引:8
|
作者
Abedi-Gaballu, Fereydoon [1 ,2 ]
Kazemi, Elham Kamal [1 ,2 ]
Salehzadeh, Seyed Ahmad [3 ]
Mansoori, Behnaz [4 ]
Eslami, Farhad [2 ]
Emami, Ali [2 ]
Dehghan, Gholamreza [2 ]
Baradaran, Behzad [1 ]
Mansoori, Behzad [5 ]
Cho, William C. [6 ]
机构
[1] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz 5166614731, Iran
[2] Univ Tabriz, Fac Nat Sci, Dept Biol, Tabriz 5166646471, Iran
[3] Tarbiat Modares Univ, Fac Med Sci, Dept Med Biotechnol, Tehran 17514115, Iran
[4] Tarbiat Modares Univ, Fac Biol Sci, Dept Mol Genet, Tehran 17514115, Iran
[5] Wistar Inst Anat & Biol, Cellular & Mol Oncogenesis Program, Philadelphia, PA 19104 USA
[6] Queen Elizabeth Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
关键词
breast cancer; reprograming; non-coding RNA; metabolic pathways; ATP CITRATE LYASE; DEHYDROGENASE KINASE 1; GLUCOSE-METABOLISM; HEXOKINASE; LACTATE-DEHYDROGENASE; REGULATES GLYCOLYSIS; LIPID-METABOLISM; ACID-METABOLISM; PYRUVATE-KINASE; TUMOR-GROWTH;
D O I
10.3390/cells11192973
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cancer cells reprogram their metabolisms to achieve high energetic requirements and produce precursors that facilitate uncontrolled cell proliferation. Metabolic reprograming involves not only the dysregulation in glucose-metabolizing regulatory enzymes, but also the enzymes engaging in the lipid and amino acid metabolisms. Nevertheless, the underlying regulatory mechanisms of reprograming are not fully understood. Non-coding RNAs (ncRNAs) as functional RNA molecules cannot translate into proteins, but they do play a regulatory role in gene expression. Moreover, ncRNAs have been demonstrated to be implicated in the metabolic modulations in breast cancer (BC) by regulating the metabolic-related enzymes. Here, we will focus on the regulatory involvement of ncRNAs (microRNA, circular RNA and long ncRNA) in BC metabolism, including glucose, lipid and glutamine metabolism. Investigation of this aspect may not only alter the approaches of BC diagnosis and prognosis, but may also open a new avenue in using ncRNA-based therapeutics for BC treatment by targeting different metabolic pathways.
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页数:23
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