Cortical abnormalities in episodic migraine: A multi-center 3T MRI study

被引:51
|
作者
Magon, Stefano [1 ,2 ]
May, Arne [3 ]
Stankewitz, Anne [3 ,4 ]
Goadsby, Peter J. [5 ,6 ]
Schankin, Christoph [7 ]
Ashina, Messoud [8 ,9 ]
Amin, Faisal M. [8 ,9 ]
Seifert, Christian L. [4 ]
Chakravarty, M. Mallar [10 ,11 ]
Mueller, Jannis [1 ]
Sprenger, Till [1 ,12 ]
机构
[1] Univ Basel, Univ Hosp Basel, Dept Neurol, Basel, Switzerland
[2] Univ Basel, Univ Hosp Basel, Med Image Anal Ctr, Basel, Switzerland
[3] Univ Hamburg, Inst Syst Neurosci, Hamburg, Germany
[4] Tech Univ Muenchen, Dept Neurol, Munich, Germany
[5] Univ Calif San Francisco, Dept Neurol, Headache Grp, San Francisco, CA 94143 USA
[6] Kings Coll London, NIHR Wellcome Trust Kings Clin Res Facil, London, England
[7] Univ Bern, Bern Univ Hosp, Dept Neurol, Inselspital, Bern, Switzerland
[8] Univ Copenhagen, Danish Headache Ctr, Copenhagen, Denmark
[9] Univ Copenhagen, Dept Neurol, Copenhagen, Denmark
[10] Douglas Mental Hlth Univ Inst Montreal, Cerebral Imaging Ctr, Montreal, PQ, Canada
[11] McGill Univ, Dept Psychiat & Biol & Biomed Engn, Montreal, PQ, Canada
[12] DKD HELIOS Klin Wiesbaden, Dept Neurol, Aukammallee 33, D-65191 Wiesbaden, Germany
关键词
Migraine; brain; magnetic resonance imaging; cortical thickness; SOMATOSENSORY CORTEX; PAIN; THICKNESS; AURA; HEADACHE;
D O I
10.1177/0333102418795163
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background Several previous studies have investigated cortical abnormalities, specifically cortical thickness, in patients with migraine, with variable results. The relatively small sample sizes of most previous studies may partially explain these inconsistencies. Objective To investigate differences of cortical thickness between control subjects and migraineurs in a large cohort. Methods Three Tesla MRI data of 131 patients (38 with and 93 without aura) and 115 control subjects were analysed. A vertex-wise linear model was applied controlling for age, gender and MRI scanner to investigate differences between groups and determine the impact of clinical factors on cortical thickness measures. Results Migraineurs showed areas of thinned cortex compared with controls bilaterally in the central sulcus, in the left middle-frontal gyrus, in left visual cortices and the right occipito-temporal gyrus. Frequency of migraine attacks and the duration of the disorder had a significant impact on cortical thickness in the sensorimotor cortex and middle-frontal gyrus. Patients without aura showed thinner cortex than controls bilaterally in the central sulcus and in the middle frontal gyrus, in the left primary visual cortices, in the left supramarginal gyrus and in the right cuneus. Patients with aura showed clusters of thinner cortex bilaterally in the subparietal sulcus (between the precuneus and posterior cingulate cortex), in the left intraparietal sulcus and in the right anterior cingulate. Conclusion These results indicate cortical abnormalities in specific brain regions in migraineurs. Some of the observed abnormalities may reflect a genetic susceptibility towards developing migraine attacks, while others are probably a consequence of repeated head pain attacks.
引用
收藏
页码:665 / 673
页数:9
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