Molecular Profiling in Non-Squamous Non-Small Cell Lung Carcinoma: Towards a Switch to Next-Generation Sequencing Reflex Testing

被引:12
|
作者
Pujol, Nina [1 ]
Heeke, Simon [2 ]
Bontoux, Christophe [3 ,4 ]
Boutros, Jacques [4 ,5 ]
Ilie, Marius [3 ,4 ]
Hofman, Veronique [3 ,4 ]
Marquette, Charles-Hugo [4 ,5 ]
Hofman, Paul [3 ,4 ]
Benzaquen, Jonathan [4 ,5 ]
机构
[1] Cote dAzur Univ, Ctr Antoine Lacassagne, Dept Radiat Oncol, F-06000 Nice, France
[2] Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA
[3] Cote dAzur Univ, Ctr Hosp Univ Nice, Lab Clin & Expt Pathol, Pasteur Hosp 1,FHU OncoAge, Biobank BB 0033 00025, F-06000 Nice, France
[4] Cote dAzur Univ, Inst Res Canc & Aging, INSERM U1081, CNRS,UMR 7284, F-06000 Nice, France
[5] Cote dAzur Univ, Ctr Hosp Univ Nice, Dept Pulm Med & Thorac Oncol, FHU OncoAge,Pasteur Hosp 1, F-06000 Nice, France
来源
JOURNAL OF PERSONALIZED MEDICINE | 2022年 / 12卷 / 10期
关键词
next-generation sequencing; predictive biomarker; non-small cell lung carcinoma; precision oncology; OPEN-LABEL; TARGETED THERAPY; CANCER PATIENTS; SOLID TUMORS; FUSION; MUTATION; IMMUNOHISTOCHEMISTRY; GENE; CHEMOTHERAPY; DRIVER;
D O I
10.3390/jpm12101684
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Molecular diagnosis of lung cancer is a constantly evolving field thanks to major advances in precision oncology. The wide range of actionable molecular alterations in non-squamous non-small cell lung carcinoma (NS-NSCLC) and the multiplicity of mechanisms of resistance to treatment resulted in the need for repeated testing to establish an accurate molecular diagnosis, as well as to track disease evolution over time. While assessing the increasing complexity of the molecular composition of tumors at baseline, as well as over time, has become increasingly challenging, the emergence and implementation of next-generation sequencing (NGS) testing has extensively facilitated molecular profiling in NS-NSCLC. In this review, we discuss recent developments in the molecular profiling of NS-NSCLC and how NGS addresses current needs, as well as how it can be implemented to address future challenges in the management of NS-NSCLC.
引用
收藏
页数:14
相关论文
共 50 条
  • [41] Expanding Broad Molecular Reflex Testing in Non-Small Cell Lung Cancer to Squamous Histology
    Zacharias, Martin
    Konjic, Selma
    Kratochwill, Nikolaus
    Absenger, Gudrun
    Terbuch, Angelika
    Jost, Philipp J.
    Wurm, Robert
    Lindenmann, Joerg
    Kashofer, Karl
    Gollowitsch, Franz
    Gorkiewicz, Gregor
    Brcic, Luka
    CANCERS, 2024, 16 (05)
  • [42] Identification of rare gene fusions in non-small cell lung cancer with next-generation sequencing
    Zhuo, M.
    Gu, W.
    Chen, R.
    Yuan, M.
    ANNALS OF ONCOLOGY, 2021, 32 : S992 - S992
  • [43] Mutational profile of non-small cell lung cancer patients: Use of next-generation sequencing
    Reis, D.
    Marques, C.
    Dias, M.
    Campainha, S.
    Cirnes, L.
    Barroso, A.
    PULMONOLOGY, 2020, 26 (01): : 50 - +
  • [44] Brief Report: Impact of Reflex Testing on Tissue-Based Molecular Genotyping in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer
    Marmarelis, Melina E.
    Scholes, Dylan G.
    Mcgrath, Cindy M.
    Priore, Salvatore F.
    Roth, Jacquelyn J.
    Feldman, Michael
    Morrissette, Jennifer J. D.
    Litzky, Leslie
    Deshpande, Charu
    Thompson, Jeffrey C.
    Doucette, Abigail
    Gabriel, Peter E.
    Sun, Lova
    Singh, Aditi P.
    Cohen, Roger B.
    Langer, Corey J.
    Carpenter, Erica L.
    Aggarwal, Charu
    CLINICAL LUNG CANCER, 2024, 25 (03) : 262 - 265.e2
  • [45] Upfront Next Generation Sequencing in Non-Small Cell Lung Cancer
    Kuang, Shelley
    Fung, Andrea S.
    Perdrizet, Kirstin A.
    Chen, Kaitlin
    Li, Janice J. N.
    Le, Lisa W.
    Cabanero, Michael
    Karsaneh, Ola Abu Al
    Tsao, Ming S.
    Morganstein, Josh
    Ranich, Laura
    Smith, Adam C.
    Wei, Cuihong
    Cheung, Carol
    Shepherd, Frances A.
    Liu, Geoffrey
    Bradbury, Penelope
    Pal, Prodipto
    Schwock, Joerg
    Sacher, Adrian G.
    Law, Jennifer H.
    Stockley, Tracy L.
    Leighl, Natasha B.
    CURRENT ONCOLOGY, 2022, 29 (07) : 4428 - 4437
  • [46] Next-Generation Sequencing with Liquid Biopsies from Treatment-Naive Non-Small Cell Lung Carcinoma Patients
    Hofman, Paul
    CANCERS, 2021, 13 (09)
  • [47] MET Amplification Prediction in Non-Small Cell Lung Carcinoma Using RNA-Based Next-Generation Sequencing
    Desmeules, P.
    Barrette, E.
    Bastien, N.
    Boudreau, D.
    Joubert, P.
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2022, 24 (10): : S106 - S106
  • [48] Targeted enrichment and next generation sequencing of non-small cell lung carcinoma FFPE samples
    du Breuil, Rusla
    Shvetsova, Tatiana
    Patel, Kruti
    Moore, Troy
    Fewell, Gwen
    CANCER RESEARCH, 2014, 74 (19)
  • [49] Targeted next-generation sequencing as a diagnostic tool for identification of druggable molecular alterations in non-small cell lung cancer
    Lechowicz, Urszula
    Szpechcinski, Adam
    Moes-Sosnowska, Joanna
    Skronska, Paulina
    Zdral, Aneta
    Rozy, Adriana
    Wojda, Emil
    Szolkowska, Malgorzata
    Orlowski, Tadeusz
    Sliwinski, Pawel
    Langfort, Reanata
    Chorostowska-Wynimko, Joanna
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2024, 32 : 558 - 559
  • [50] Validating a targeted next-generation sequencing assay and profiling somatic variants in Chinese non-small cell lung cancer patients
    Ruirui Jiang
    Bo Zhang
    Xiaodong Teng
    Peizhen Hu
    Sanpeng Xu
    Zuyu Zheng
    Rui Liu
    Tingdong Tang
    Feng Ye
    Scientific Reports, 10