MLN0128 (INK128), an Investigational Oral Dual TORC1/2 Inhibitor, in Patients (pts) with Relapsed or Refractory Multiple Myeloma (MM), Non-Hodgkin's Lymphoma (NHL), or Waldenstrom Macroglobulinemia (WM): Preliminary Results From a Phase 1 Dose-Escalation Study

被引:1
|
作者
Ghobrial, Irene M. [1 ,2 ]
Siegel, David [3 ]
Vij, Ravi [4 ]
Wolf, Jeffrey L. [5 ]
Berdeja, Jesus G. [6 ]
Matous, Jeffrey V. [7 ]
Lipman, Peter [8 ]
Patel, Chirag [8 ]
Le, Trinh [9 ]
Rommel, Christian [9 ]
Berk, Gregory [8 ]
机构
[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, LeBow Inst Myeloma Therapeut, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Ctr Multiple Myeloma Res, Boston, MA 02115 USA
[3] Hackensack Univ Med Ctr, Hackensack, NJ USA
[4] Washington Univ Sch Med, Div Oncol, Dept Med, St Louis, MO USA
[5] Univ Calif San Francisco, San Francisco, CA 94143 USA
[6] Sarah Cannon Res Inst, Nashville, TN USA
[7] Colorado Blood Canc Inst, Denver, CO USA
[8] Millennium Pharmaceut Inc, Cambridge, MA USA
[9] Intellikine LLC, La Jolla, CA USA
关键词
D O I
10.1182/blood.V120.21.4038.4038
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
4038
引用
收藏
页数:2
相关论文
共 50 条
  • [41] LOXO-305, A Next Generation, Highly Selective, Non-Covalent BTK Inhibitor in Previously Treated Mantle Cell Lymphoma, Waldenstrom's Macroglobulinemia, and Other Non-Hodgkin Lymphomas: Results from the Phase 1/2 BRUIN Study
    Wang, Michael
    Shah, Nirav N.
    Alencar, Alvaro J.
    Gerson, James N.
    Patel, Manish R.
    Fakhri, Bita
    Jurczak, Wojciech
    Tan, Xuan Ni
    Lewis, Katharine L.
    Fenske, Timothy S.
    Coombs, Catherine C.
    Flinn, Ian W.
    Lewis, David John
    Le Gouill, Steven
    Palomba, M. Lia
    Woyach, Jennifer A.
    Pagel, John M.
    Lamanna, Nicole
    Cohen, Jonathon B.
    Barve, Minal
    Ghia, Paolo
    Eyre, Toby A.
    Yin, Ming
    Nair, Binoj
    Tsai, Donald
    Ku, Nora C.
    Mato, Anthony
    Cheah, Chan Yoon
    BLOOD, 2020, 136
  • [42] MBS303, a Novel 2:1 CD20xCD3 Bispecific Antibody, Demonstrated a Favorable Safety and Potent Antitumor Activity in Patients with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma: Preliminary Results from a Phase I , Dose-Escalation Trial
    Song, Yuqin
    Yang, Haiyan
    Jia, Youchao
    Sheng, Lixia
    Deng, Lijuan
    Chen, Xi
    Tang, Yongjing
    Liu, Xifang
    Liu, Sijun
    Wei, Min
    Li, Feng
    BLOOD, 2024, 144 : 6481 - 6482
  • [45] Clinical Activity of CC-99282, a Novel, Oral Small Molecule Cereblon E3 Ligase Modulator (CELMoD) Agent, in Patients (Pts) with Relapsed or Refractory Non-Hodgkin Lymphoma (R/R NHL) - First Results from a Phase 1, Open-Label Study
    Michot, Jean-Marie
    Chavez, Julio C.
    Carpio, Cecilia
    Ferrari, Silvia
    Feldman, Tatyana A.
    Morillo, Daniel
    Kuruvilla, John
    Pinto, Antonio
    Ribrag, Vincent
    Bachy, Emmanuel
    Buchholz, Tonia J.
    Carrancio, Soraya
    Guarinos, Carla
    Wu, Fan
    Li, Shaoyi
    Patah, Poliana
    Pourdehnad, Michael
    Nastoupil, Loretta
    BLOOD, 2021, 138
  • [46] Preliminary results from the Phase I part of a first-in-human Phase I/II study of HH2853, an EZH1/2 inhibitor, in patients with relapsed/refractory non-Hodgkin lymphomas or advanced solid tumors
    Fan, Zhengfu
    Wang, Jin
    Fang, Meiyu
    Patrick, Johnston
    Han, Tun
    Sommerhalder, David
    Gong, Jifang
    Yang, Jilong
    Yang, Yun
    Munoz, Javier
    Song, Yuqin
    Li, Zhiming
    Li, Xian'an
    Ma, Qiuying
    Han, Jinming
    Shen, Lin
    Zhu, Jun
    CANCER RESEARCH, 2023, 83 (08)
  • [47] A phase I, open-label study of GSK2816126, an enhancer of zeste homolog 2 (EZH2) inhibitor, in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL), transformed follicular lymphoma (tFL), other non-Hodgkin's lymphomas (NHL), multiple myeloma (MM) and solid tumor.
    Yap, Timothy Anthony
    Johnson, Peter W. M.
    Winter, Jane
    Leonard, John
    Giulino-Roth, Lisa
    Horner, Thierry
    Radswillas, Kristen
    Carver, Jennifer
    Dhar, Arindam
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [48] Glofitamab Plus R-CHOP Induces High Response Rates with Minimal Cytokine Release Syndrome (CRS) in Patients (pts) with Relapsed/Refractory (R/R) NonHodgkin Lymphoma (NHL) and Previously Untreated (1L) Diffuse Large B-Cell Lymphoma (DLBCL): Preliminary Results from a Dose-Escalation and Safety Run-in Phase Ib Study
    Ghosh, Nilanjan
    Townsend, William
    Dickinson, Michael
    Topp, Max
    Tani, Monica
    Santoro, Armando
    Crump, Michael
    Morschhauser, Franck
    Le Gouill, Steven
    Mehta, Amitkumar
    Panchal, Anesh
    Wu, Chun
    Barrett, Martin
    Humphrey, Kathryn
    Qayum, Naseer
    Hutchings, Martin
    BLOOD, 2021, 138
  • [49] Preliminary Safety and Efficacy Evaluation of IMM0306, a CD47 and CD20 Bispecific Monoclonal Antibody-Trap (mAbTrap), from an Ongoing Phase I Dose-Escalation Study in Patients with Relapsed or Refractory B-Cell Non- Hodgkin's Lymphoma (R/R B-NHL)
    Shi, Yuankai
    Song, Yongping
    Zhang, Mingzhi
    Jing, Hongmei
    Wang, Zhen
    Li, Zhiming
    Qi, Junyuan
    Li, Fei
    Li, Wenyu
    Yang, Jianliang
    Gao, Siman
    Ma, Huizi
    He, Heming
    Lu, Qiying
    Tian, Wenzhi
    BLOOD, 2022, 140 : 9323 - 9324
  • [50] CC-92480, a Potent, Novel Cereblon E3 Ligase Modulator (CELMoD) Agent, in Combination with Dexamethasone (DEX) and Bortezomib (BORT) in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Preliminary Results from the Phase 1/2 Study CC-92480-MM-002
    Richardson, Paul G.
    Ocio, Enrique
    Raje, Noopur S.
    Gregory, Tara
    White, Darrell
    Oriol, Albert
    Sandhu, Irwindeep
    Raab, Marc-Steffen
    Le Blanc, Richard
    Rodriguez, Cesar
    Trudel, Suzanne
    Waesch, Ralph
    Perrot, Aurore
    Bahlis, Nizar J.
    Zhou, Zehua
    Lamba, Manisha
    Amatangelo, Michael
    Civardi, Tiziana
    Katz, Jessica
    Aciag, Paulo M.
    Peluso, Teresa
    Dimopoulos, Meletios A.
    BLOOD, 2021, 138