Evaluation of In Vitro Antimalarial Activity of Different Extracts of Eremostachys azerbaijanica Rech.f.

被引：0
|
作者：
Asnaashari, Solmaz [1 ]
Afshar, Fariba Heshmati [1 ,2 ]
Moghadam, Sedigheh Bamdad [1 ]
Delazar, Abbas [1 ,2 ]
机构：
[1] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Dept Pharmacognosy, Fac Pharm, Tabriz, Iran
来源：
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH | 2016年 / 15卷 / 03期
关键词：
Antimalaria; Eremostachys azerbaijanica; Cell free assay; GC-MS; BETA-HEMATIN FORMATION; MEDICINAL-PLANTS; MALARIA; FLAVONOIDS; DEGRADATION;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Six extracts with different polarity from aerial parts and rhizomes of Eremostachys azerbaijanica Rech. f., were screened for their antimalarial properties by cell free beta-hematin formation assay. Dichloromethane (DCM) extracts of both parts of plant showed significant antimalarial activities with IC50 values of 0.949 +/- 0.061 mg/mL in aerial parts and 0.382 +/- 0.011 mg/mL in rhizomes. Bioactivity-guided fractionation of the most potent part (DCM extract of rhizomes) by vacuum liquid chromatography (VLC) afforded seven fractions. Two fractions [100% Ethyl acetate (EtOAC) and 100% Methatol (MeOH)] showed considerable antimalarial activity with IC50 values of 0.335 +/- 0.033 mg/mL and 0.403 +/- 0.037 mg/mL, respectively. According to GC-MS analysis, the sesquiterpene, steroid and coumarin derivatives are the main constituents of the most potent fractions; therefore, it seems that the anti malarial activity of these fractions may be related to the presence of these types of compounds.
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页码：523 / 529
页数：7
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