Prenatal exposure to pyrrolizidine alkaloids induced hepatotoxicity and pulmonary injury in fetal rats

被引:10
|
作者
Guo, Yu [1 ,3 ]
Xiao, Di [1 ]
Yang, Xiaojing [4 ]
Zheng, Jiang [4 ,5 ]
Hu, Shuwei [1 ]
Wu, Panfeng [1 ]
Li, Xiaoxia [1 ]
Kou, Hao [2 ,3 ]
Wang, Hui [1 ,3 ]
机构
[1] Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
[2] Wuhan Univ, Dept Pharm, Zhongnan Hosp, Wuhan 40071, Hubei, Peoples R China
[3] Hubei Prov Key Lab Developmentally Originated Dis, Wuhan 430071, Hubei, Peoples R China
[4] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Liaoning, Peoples R China
[5] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Key Lab Pharmaceut Guizhou Prov, Guiyang 550025, Guizhou, Peoples R China
基金
中国国家自然科学基金;
关键词
Bioactivation; Cytochrome P450; Pulmonary toxicities; Liver injury/toxicity; Reactive metabolites/intermediates; OXIDATIVE STRESS; ASSAY; MONOCROTALINE; GLUTATHIONE; METABOLITES; ACTIVATION; RESPONSES; TOXICITY; DISEASE;
D O I
10.1016/j.reprotox.2019.02.006
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Hepatic and pulmonary toxicity in fetal rats induced by pyrrolizidine alkaloids (PAs) was investigated. Retrorsine (RTS) or monocrotaline (MCT) was intragastrically administered during pregnancy. The reduction of body and tail lengths was consistent with body weight loss in PA-exposed fetuses, and pathological lesions in liver and lung were observed only in fetuses. Both PAs reduced fetal serum transaminase activities. The GSH/GSSG ratio, GSH peroxidase and superoxide dismutase activities also decreased but glutathione S-transferase activity increased in fetal lung, especially for MCT. The pyrrole-protein adducts in fetal liver and lung could be detected, and those adducts in RTS fetal lungs were about 65% of those in MCT group. In conclusion, prenatal PAs exposure induced fetal hepatic and pulmonary toxicities through the generation of pyrrole metabolites and oxidative injury. The difference on fetal pulmonary redox homeostasis between two PAs groups might be associated with the content of PAs migrated to fetal lungs.
引用
收藏
页码:34 / 41
页数:8
相关论文
共 50 条
  • [41] THE EFFECT OF PRENATAL COCAINE EXPOSURE ON UMBILICAL-CORD LENGTH IN FETAL RATS
    BARRON, S
    FOSS, JA
    RILEY, EP
    NEUROTOXICOLOGY AND TERATOLOGY, 1991, 13 (05) : 503 - 506
  • [42] Prenatal exposure to exogenous progesterone adversely affects fetal development in Albino rats
    Tag, Hend M.
    Elgawish, Rania Abdelrahman
    Ebaid, Hala M.
    Abdel-Rahman, Mona
    Abdelrazek, Heba M. A.
    JOURNAL OF BASIC AND APPLIED ZOOLOGY, 2021, 82 (01):
  • [43] THE EFFECT OF PRENATAL EXPOSURE ON DISPOSITION OF HEXACHLORONAPHTHALENE IN FEMALE WISTAR RATS AND FETAL COMPARTMENT
    Stragierowicz, Joanna
    Sitarek, Krystyna
    Grobelski, Bartlomiej
    Kilanowicz, Anna
    INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH, 2018, 31 (05) : 685 - 695
  • [44] Prenatal exposure to exogenous progesterone adversely affects fetal development in Albino rats
    Hend M. Tag
    Rania Abdelrahman Elgawish
    Hala M. Ebaid
    Mona Abdel-Rahman
    Heba M. A. Abdelrazek
    The Journal of Basic and Applied Zoology, 82 (1):
  • [45] THE EFFECT OF PRENATAL ALCOHOL EXPOSURE ON UMBILICAL-CORD LENGTH IN THE FETAL RATS
    BARRON, S
    RILEY, EP
    SMOTHERMAN, WP
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1986, 10 (05) : 493 - 495
  • [46] Sex difference in monocrotaline-induced developmental toxicity and fetal hepatotoxicity in rats
    Luo, Jinyuan
    Yang, Xiaojing
    Qiu, Shuaikai
    Li, Xia
    Xiang, E.
    Fang, Yan
    Wang, Yanqing
    Zhang, Li
    Wang, Hui
    Zheng, Jiang
    Guo, Yu
    TOXICOLOGY, 2019, 418 : 32 - 40
  • [47] Prenatal arsenic exposure induces immunometabolic alteration and renal injury in rats
    Singh, Radha Dutt
    Tiwari, Ratnakar
    Sharma, Vineeta
    Khan, Hafizurrahman
    Gangopadhyay, Siddhartha
    Singh, Sukhveer
    Koshta, Kavita
    Shukla, Shagun
    Arjaria, Nidhi
    Mandrah, Kapil
    Jagdale, Pankaj Ramji
    Patnaik, Satyakam
    Roy, Somendu Kumar
    Singh, Dhirendra
    Giri, Ashok Kumar
    Srivastava, Vikas
    FRONTIERS IN MEDICINE, 2023, 9
  • [48] MONOCROTALINE-INDUCED PULMONARY INJURY IN RATS
    MOLTENI, A
    WARD, WF
    TSAO, C
    PORT, CD
    SOLLIDAY, N
    FEDERATION PROCEEDINGS, 1983, 42 (04) : 778 - 778
  • [49] Cerebellar morphological alterations in rats induced by prenatal ozone exposure
    Rivas-Manzano, P
    Paz, C
    NEUROSCIENCE LETTERS, 1999, 276 (01) : 37 - 40
  • [50] Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction
    Xu, Jie
    Xiong, Aizhen
    Wang, Xunjiang
    Yan, Xing
    Chen, Yilin
    Ye, Xuanling
    Wang, Zhengtao
    Ding, Lili
    Yang, Li
    ARCHIVES OF PHARMACAL RESEARCH, 2023, 46 (08) : 694 - 712