Does molecular biology play any role in ductal carcinoma in situ?

被引：0

作者：

Sakr, R. A. ^{[1
]}

机构：

[1] Univ Paris 06, Hop Tenon, Gynecol Serv, UMRS938, F-75020 Paris, France

来源：

GYNECOLOGIE OBSTETRIQUE & FERTILITE | 2013年 / 41卷 / 01期

关键词：

Ductal carcinoma in situ; Biomarker; INVASIVE BREAST-CANCER; SURGICAL ADJUVANT BREAST; LYMPH-NODE BIOPSY; HORMONE-RECEPTOR STATUS; LOCAL RECURRENCE; RISK-FACTORS; CYCLIN D1; PROGNOSTIC-SIGNIFICANCE; INTRADUCTAL-CARCINOMA; CONSERVING SURGERY;

D O I：

10.1016/j.gyobfe.2012.11.004

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The natural history of ductal carcinoma in situ (DCIS) is not fully elucidated, but it is recognized that DCIS is the true precursor of invasive carcinoma. Studies could show that DCIS is as heterogeneous as invasive ductal carcinoma, yet, they were unable to predict which DCIS will progress to invasion. Several biomarkers were also demonstrated to have a certain prognostic value. However, except for estrogen receptors and HER2, biomarkers are not yet widely used in clinical practice since their predictive value has not proven to be better than the grade and the classical classifying systems of DCIS. Identifying biomarkers for risk of invasiveness in DOS could be of great value to help high risk patients through the management of their disease and to avoid overtreatment in low risk patients. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：45 / 53

页数：9

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