Cembrane Derivatives from the Soft Corals, Sinularia gaweli and Sinularia flexibilis

被引：22

作者：

Hu, Li-Chung ^{[1
,2
,3
,4
]}

Yen, Wei-Hsuan ^{[1
,2
,3
,4
]}

Su, Jui-Hsin ^{[1
,2
,3
,4
]}

Chiang, Michael Yen-Nan ^{[5
]}

Wen, Zhi-Hong ^{[6
,7
]}

Chen, Wu-Fu ^{[8
,9
]}

Lu, Ting-Jang ^{[10
]}

Chang, Yu-Wei ^{[11
]}

Chen, Yung-Husan ^{[4
]}

Wang, Wei-Hsien ^{[4
,6
,7
]}

Wu, Yang-Chang ^{[12
,13
,14
]}

Sung, Ping-Jyun ^{[1
,2
,3
,4
,6
,7
,15
]}

机构：

[1] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan

[2] Natl Dong Hwa Univ, Dept Life Sci, Pingtung 944, Taiwan

[3] Natl Dong Hwa Univ, Inst Biotechnol, Pingtung 944, Taiwan

[4] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[5] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

[6] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[7] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

[8] Kaohsiung Chang Gung Mem Hosp, Dept Neurosurg, Kaohsiung 833, Taiwan

[9] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan

[10] Natl Taiwan Univ, Grad Inst Food Sci & Technol, Taipei 106, Taiwan

[11] Natl Taiwan Ocean Univ, Dept Food Sci, Keelung 202, Taiwan

[12] China Med Univ, Sch Pharm, Coll Pharm, Taichung 404, Taiwan

[13] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 404, Taiwan

[14] China Med Univ Hosp, Ctr Mol Med, Taichung 404, Taiwan

[15] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

MARINE DRUGS | 2013年 / 11卷 / 06期

关键词：

cembrane; norcembrane; Sinularia flexibilis; Sinularia gaweli; X-ray; anti-inflammatory activity; OXYGENATED CEMBRANOIDS; MARINE-INVERTEBRATES; DITERPENES; 11-DEHYDROSINULARIOLIDE; COMPOUND; COELENTERATA;

D O I：

10.3390/md11062154

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new norcembranoidal diterpene, 1-epi-sinulanorcembranolide A (1), and a new cembranoidal diterpene, flexibilin D (2), were isolated from the soft corals, Sinularia gaweli and Sinularia flexibilis, respectively. The structures of new metabolites 1 and 2 were elucidated by spectroscopic methods, and compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. In addition, S. flexibilis yielded a known cembrane, 5-dehydrosinulariolide (3); the structure, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis.

引用

页码：2154 / 2167

页数：14

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