Native Mass Spectrometry Sheds Light on Formation of Deadly Heparin-PF4 Complexes

被引:1
|
作者
Zaia, Joseph [1 ]
机构
[1] Boston Univ, Dept Biochem, Med Campus, Boston, MA 02215 USA
关键词
D O I
10.1016/j.bpj.2020.07.040
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
引用
收藏
页码:1267 / 1267
页数:1
相关论文
共 50 条
  • [21] Effect of functional Heparin-PF4 antibodies from patients with heparin-induced thrombocytopenia on blood coagulation assessed by thrombelastography.
    Ahmad, S
    Desai, H
    Siddiqui, FA
    Walker, JM
    Dorfman, R
    Amirkhosravi, A
    Francis, JL
    BLOOD, 2003, 102 (11) : 115B - 115B
  • [22] Bovine heparin generates significantly more functional heparin-PF4 antibodies of the IgG subtype than porcine heparin following cardiac surgery.
    Ahmad, S
    Walker, JM
    Drexler, A
    Reyes, E
    Palmer, GJ
    Moroose, R
    Francis, JL
    BLOOD, 2003, 102 (11) : 805A - 805A
  • [23] Standard Proteoforms and Their Complexes for Native Mass Spectrometry
    Schachner, Luis F.
    Ives, Ashley N.
    McGee, John P.
    Melani, Rafael D.
    Kafader, Jared O.
    Compton, Philip D.
    Patrie, Steven M.
    Kelleher, Neil L.
    Journal of the American Society for Mass Spectrometry, 2019, 30 (07): : 1190 - 1198
  • [24] Standard Proteoforms and Their Complexes for Native Mass Spectrometry
    Schachner, Luis F.
    Ives, Ashley N.
    McGee, John P.
    Melani, Rafael D.
    Kafader, Jared O.
    Compton, Philip D.
    Patrie, Steven M.
    Kelleher, Neil L.
    JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2019, 30 (07) : 1190 - 1198
  • [25] B cells, PF4/heparin complexes, and complement
    Warkentin, Theodore E.
    BLOOD, 2016, 128 (14) : 1781 - 1782
  • [26] Mechanism of Complement Activation By PF4/ Heparin Complexes
    Khandelwal, Sanjay
    Alexandra, Johnson M.
    Hester, C. Garren
    Frank, Michael M.
    Arepally, Gowthami M.
    BLOOD, 2016, 128 (22)
  • [27] Characterization of HIT-associated heparin-PF4 antibodies in Asian-Indians: Relevance to inflammatory markers.
    Kannan, M
    Ahmad, S
    Ahmed, R
    Kale, S
    Hoppensteadt, DA
    Fareed, J
    Saxena, R
    BLOOD, 2003, 102 (11) : 88B - 89B
  • [28] Low sulfated heparin (ODSH) interferes with anti-PF4/heparin antibody induced platelet activation by disrupting PF4/heparin complexes
    Krauel, K.
    Hackbarth, C.
    Fuerll, B.
    Greinacher, A.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 : 192 - 192
  • [29] Novel Immunoassay for Complement Activation by PF4/Heparin Complexes
    Khandelwal, Sanjay
    Johnson, Alexandra M.
    Liu, Jian
    Keire, David
    Sommers, Cynthia
    Ravi, Joann
    Lee, Grace M.
    Lambris, John D.
    Reis, Edimara S.
    Arepally, Gowthami M.
    THROMBOSIS AND HAEMOSTASIS, 2018, 118 (08) : 1484 - 1487
  • [30] Fibronectin modulates formation of PF4/heparin complexes and is a potential factor for reducing risk of developing HIT
    Krauel, Krystin
    Preusse, Patricia
    Warkentin, Theodore E.
    Trabhardt, Catja
    Brandt, Sven
    Jensch, Inga
    Mandelkow, Martin
    Hammer, Elke
    Hammerschmidt, Sven
    Greinacher, Andreas
    BLOOD, 2019, 133 (09) : 978 - 989