Purpose: To compare regional variations in lamina cribrosa (LC) curvature and depth between healthy eyes (group 1) and naive eyes with primary open-angle glaucoma (POAG) having superior (group 2), inferior (group 3), and both (group 4) hemifield retinal nerve fiber layer (RNFL) defects. Design: Cross-sectional study. Participants: Each group consisted of 39 eyes of 39 Korean patients who were matched for age, sex, and axial length. Methods: The LC curvature index (LCCI) and LC depth (LCD) were measured in B-scan images obtained using enhanced depth imaging OCT at 7 locations spaced equidistantly across the vertical optic disc diameter. Superior and inferior LCCI and LCD were compared by calculating the superior-to-inferior (Sup/Inf) ratios. Main Outcome Measures: Comparisons of LCCI, LCD, and Sup/Inf ratio among the 4 groups. Results: Compared with healthy eyes (group 1), LCCIs were larger at the superior and middle planes in group 2, at the inferior and middle planes in group 3, and at all planes in group 4 (P <= 0.003). The LCD showed similar results, but there was no difference in superior planes between groups 1 and 2. The Sup/Inf ratio of LCCI differed significantly between groups 1 (1.03) and 2 (1.20), groups 1 and 3 (0.79), groups 2 and 3, groups 2 and 4 (0.96), and groups 3 and 4 (all P < 0.001), but not between groups 1 and 4 (P = 0.273). The Sup/Inf ratio of LCD differed only between groups 2 and 3 (P = 0.002). Conclusions: Eyes with POAG showed regional differences in LC morphology, corresponding with the location of RNFL defects. The regional variations in LCCI suggest that LC morphology in POAG would be better assessed on a regional basis than by a global index. (C) 2019 by the American Academy of Ophthalmology
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Seoul Natl Univ, Coll Med, Ophthalmol, Seoul, South Korea
Seoul Natl Univ Hosp, Ophthalmol, Seoul, South KoreaSeoul Natl Univ, Coll Med, Ophthalmol, Seoul, South Korea
Kim, KoEun
Jeoung, Jin Wook
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Seoul Natl Univ, Coll Med, Ophthalmol, Seoul, South Korea
Seoul Natl Univ Hosp, Ophthalmol, Seoul, South KoreaSeoul Natl Univ, Coll Med, Ophthalmol, Seoul, South Korea
Jeoung, Jin Wook
Kim, Young Kook
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Seoul Natl Univ, Coll Med, Ophthalmol, Seoul, South Korea
Seoul Natl Univ Hosp, Ophthalmol, Seoul, South KoreaSeoul Natl Univ, Coll Med, Ophthalmol, Seoul, South Korea
Kim, Young Kook
Seol, Bo Ram
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Seoul Natl Univ, Coll Med, Ophthalmol, Seoul, South Korea
Seoul Natl Univ Hosp, Ophthalmol, Seoul, South KoreaSeoul Natl Univ, Coll Med, Ophthalmol, Seoul, South Korea
Seol, Bo Ram
Park, Ki Ho
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Seoul Natl Univ, Coll Med, Ophthalmol, Seoul, South Korea
Seoul Natl Univ Hosp, Ophthalmol, Seoul, South KoreaSeoul Natl Univ, Coll Med, Ophthalmol, Seoul, South Korea
Park, Ki Ho
Kim, Dong Myung
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Seoul Natl Univ, Coll Med, Ophthalmol, Seoul, South Korea
Seoul Natl Univ Hosp, Ophthalmol, Seoul, South KoreaSeoul Natl Univ, Coll Med, Ophthalmol, Seoul, South Korea
机构:
Univ N Texas, Dept Cell Biol & Anat, Ft Worth, TX USA
Univ N Texas, North Texas Eye Res Inst, Ft Worth, TX USAUniv Coll Dublin, Sch Med & Hlth Sci, Dublin 2, Ireland
Clark, Abbot F.
O'Brien, Colm J.
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Univ Coll Dublin, Sch Med & Hlth Sci, Dublin 2, Ireland
Mater Misericordiae Univ Hosp, Inst Ophthalmol, Dublin, IrelandUniv Coll Dublin, Sch Med & Hlth Sci, Dublin 2, Ireland
O'Brien, Colm J.
Wallace, Deborah M.
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Univ Coll Dublin, Sch Med & Hlth Sci, Dublin 2, Ireland
Mater Misericordiae Univ Hosp, Inst Ophthalmol, Dublin, IrelandUniv Coll Dublin, Sch Med & Hlth Sci, Dublin 2, Ireland
机构:
Univ Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USA
Inje Univ, Haeundae Paik Hosp, Ophthalmol, Busan, South KoreaUniv Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USA
Suh, Min Hee
Zangwill, Linda M.
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Univ Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USAUniv Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USA
Zangwill, Linda M.
Belghith, Akram
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Univ Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USAUniv Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USA
Belghith, Akram
Yarmohammadi, Adeleh
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Univ Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USAUniv Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USA
Yarmohammadi, Adeleh
Manalastas, Patricia Isabel C.
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Univ Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USAUniv Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USA
Manalastas, Patricia Isabel C.
Diniz-Filho, Alberto
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Univ Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USAUniv Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USA
Diniz-Filho, Alberto
Fatehee, Naeem
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Univ Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USAUniv Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USA
Fatehee, Naeem
Yousefi, Siamak
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Univ Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USAUniv Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USA
Yousefi, Siamak
Weinreb, Robert N.
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Univ Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USAUniv Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Ophthalmol, San Diego, CA 92103 USA