Near-Infrared (NIR)-Absorbing Conjugated Polymer Dots as Highly Effective Photothermal Materials for In Vivo Cancer Therapy

被引：200

作者：

Li, Shengliang ^{[1
]}

Wang, Xiaoyu ^{[1
]}

Hu, Rong ^{[1
]}

Chen, Hui ^{[1
]}

Li, Meng ^{[1
]}

Wang, Jianwu ^{[1
]}

Wang, Yunxia ^{[1
]}

Liu, Libing ^{[1
]}

Lv, Fengting ^{[1
]}

Liang, Xing-Jie ^{[2
]}

Wang, Shu ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Ctr Excellence Nanosci, Beijing 100190, Peoples R China

来源：

CHEMISTRY OF MATERIALS | 2016年 / 28卷 / 23期

关键词：

CONVERSION EFFICIENCY; ENERGY-TRANSFER; NANOPARTICLES; CELLS; FLUORESCENCE; OXYGEN; MORPHOLOGY; NANOPROBE; ABLATION; AGENT;

D O I：

10.1021/acs.chemmater.6b03738

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Photothermal therapy (PTT) holds great promise for noninvasive cancer treatment. To fulfill this goal, highly effective and low-risk photothermal agents have been intensively explored. Here, we present a new PTT material based on conjugated polymer dots (Pdots) that exhibit strong near-infrared (NIR) absorption and high photostability. The Pdots result in a thermal response upon illumination with a NIR laser, leading to a high photothermal conversion efficiency of 65%. Thus, the photothermal ablation of cancer cells using the Pdots both in vitro and in vivo can be achieved, highlighting the potential of Pdots as a nanoplatform for clinical therapy. They also open up a new avenue to develop new photothermal therapeutic materials.

引用

页码：8669 / 8675

页数：7

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