Synthesis and receptor binding evaluation of clavizepine analogues with no ring D substituents

被引：11
|
作者：
de la Fuente, MC
Pullan, SE
Biesmans, I
Domínguez, D
机构：
[1] Univ Santiago de Compostela, Fac Quim, CSIC, Dept Quim Organ, Santiago De Compostela 15782, Spain
[2] Johnson & Johnson PRD, Div Psychiat, B-2340 Beerse, Belgium
[3] Univ Santiago de Compostela, Fac Quim, CSIC, Unidad Asoc, Santiago De Compostela 15782, Spain
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 10期
关键词：
D O I：
10.1021/jo052320c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Assembly of the azepine ring of xantheno[9,1-cd]azepines by electrophilic cyclization of sulfonamide acetals provides access to clavizepine analogues in the form of 2,12b-dihydroor 4-hydroxy-2,3,4,12b-tetrahydro-1H-xantheno[9,1-cd] azepines, in the latter case producing the trans derivative stereoselectively. Binding assays for clavizepine and analogues at adrenergic, dopaminergic, and serotonergic receptors are reported.
引用
收藏
页码：3963 / 3966
页数：4
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