Synthesis of 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(substituted phenyl)pyrimidin-2-ol Analogues as Anti-Inflammatory and Analgesic Agents

被引：0

作者：

Alam, Muhammad Jahangir ^{[1
]}

Ahsan, Mohamed Jawed ^{[2
]}

Alam, Ozair ^{[1
]}

Khan, Suroor Ahmad ^{[1
]}

机构：

[1] Jamia Hamdard, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India

[2] Maharishi Arvind Coll Pharm, Dept Pharmaceut Chem, Jaipur 302023, Rajasthan, India

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2013年 / 10卷 / 08期

关键词：

Anti-inflammatory activity; Analgesic activity; Osiris software; Pyrazole; Ulcerogenicity; ANTIMYCOBACTERIAL EVALUATION; ANTICONVULSANT ACTIVITY; IN-VITRO; DERIVATIVES; SERUM;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 16 novel 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(substituted-phenyl) pyrimidin-2-ol analogues was synthesized in satisfactory yields after toxicity prediction and drug score studies by Osiris software followed by anti-inflammatory, analgesic, ulcerogenic, and lipid peroxidation activities of 10 compounds by the known reported methods. 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(4-chlorophenyl)pyrimidin-2-ol (6g) was found to be a potent compound of the series showed good anti-inflammatory (81.91 +/- 7.69% inhibition) and analgesic activity (53.25 +/- 2.91) with less ulcerogenic effects (0.66 +/- 0.40).

引用

页码：776 / 782

页数：7

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