Introduction: Multiple sclerosis is an inflammatory disease that attacks the central nervous system CNS (brain and spinal cord). Specifically, it attacks the myeline sheath of the neuron cells (1-3). Up to now there is no known pathophysiological cause of the MS disease but it is believed to be autoimmune. Autoimmune means the immunity system attacks normal tissues without obvious cause. It results in progressive neurological deficits leading to accumulating disabilities. The wide distribution of plaques (name of MS lesion) produces a variety of clinical symptoms.
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Univ Vita Salute San Raffaele, Neuroimaging Res Unit, Inst Expt Neurol, Div Neurosci,San Raffaele Sci Inst, Via Olgettina 60, I-20132 Milan, ItalyUniv Vita Salute San Raffaele, Neuroimaging Res Unit, Inst Expt Neurol, Div Neurosci,San Raffaele Sci Inst, Via Olgettina 60, I-20132 Milan, Italy
Filippi, Massimo
Preziosa, Paolo
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Univ Vita Salute San Raffaele, Neuroimaging Res Unit, Inst Expt Neurol, Div Neurosci,San Raffaele Sci Inst, Via Olgettina 60, I-20132 Milan, ItalyUniv Vita Salute San Raffaele, Neuroimaging Res Unit, Inst Expt Neurol, Div Neurosci,San Raffaele Sci Inst, Via Olgettina 60, I-20132 Milan, Italy
Preziosa, Paolo
Rocca, Maria A.
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Univ Vita Salute San Raffaele, Neuroimaging Res Unit, Inst Expt Neurol, Div Neurosci,San Raffaele Sci Inst, Via Olgettina 60, I-20132 Milan, ItalyUniv Vita Salute San Raffaele, Neuroimaging Res Unit, Inst Expt Neurol, Div Neurosci,San Raffaele Sci Inst, Via Olgettina 60, I-20132 Milan, Italy
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Hosp Univ Vall Hebron, Magnet Resonance Unit IDI, Dept Radiol, Serv Radiol, Barcelona 08035, SpainHosp Univ Vall Hebron, Magnet Resonance Unit IDI, Dept Radiol, Serv Radiol, Barcelona 08035, Spain
Rovira, Alex
Leon, Adelaida
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Hosp Univ Vall Hebron, Magnet Resonance Unit IDI, Dept Radiol, Serv Radiol, Barcelona 08035, SpainHosp Univ Vall Hebron, Magnet Resonance Unit IDI, Dept Radiol, Serv Radiol, Barcelona 08035, Spain