Alternative Splicing in Angiogenesis

被引：87

作者：

Bowler, Elizabeth ^{[1
]}

Oltean, Sebastian ^{[1
]}

机构：

[1] Univ Exeter, Coll Med & Hlth, Med Sch, Inst Biomed & Clin Sci, Exeter EX4 4PY, Devon, England

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 09期

基金：

英国生物技术与生命科学研究理事会;

关键词：

alternative splicing; angiogenesis; VEGF; VEGFR; NRP; FGFR; vasohibin; HIF-1; angiopoietin; ENDOTHELIAL GROWTH-FACTOR; PAS DOMAIN PROTEIN; FACTOR-RECEPTOR; STRUCTURAL BASIS; HEPARIN-BINDING; TUMOR-GROWTH; FACTOR SRSF1; FACTOR-A; SIGNAL-TRANSDUCTION; GENOMIC STRUCTURE;

D O I：

10.3390/ijms20092067

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct functions. In fact, splice isoforms can have opposing functions and there are many instances whereby a splice isoform acts as an inhibitor of canonical isoform function, thereby adding an additional layer of regulation to important processes. Angiogenesis is an important process that is governed by alternative splicing mechanisms. This review focuses on the alternative spliced isoforms of key genes that are involved in the angiogenesis process; VEGF-A, VEGFR1, VEGFR2, NRP-1, FGFRs, Vasohibin-1, Vasohibin-2, HIF-1, Angiopoietin-1 and Angiopoietin-2.

引用

页数：27

共 50 条

[41] Chromatin and Alternative Splicing
Allo, M.
Schor, I. E.
Munoz, M. J.
de la Mata, M.
Agirre, E.
Valcarcel, J.
Eyras, E.
Kornblihtt, A. R.
NUCLEAR ORGANIZATION AND FUNCTION, 2010, 75 : 103 - 111
[42] Alternative splicing in parallel
Grabowski, P
NATURE BIOTECHNOLOGY, 2002, 20 (04) : 346 - 347
[43] Diverse alternative back-splicing and alternative splicing landscape of circular RNAs
Zhang, Xiao-Ou
Dong, Rui
Zhang, Yang
Zhang, Jia-Lin
Luo, Zheng
Zhang, Jun
Chen, Ling-Ling
Yang, Li
GENOME RESEARCH, 2016, 26 (09) : 1277 - 1287
[44] Angiogenesis - Alternative pathways
Novak, K
NATURE REVIEWS CANCER, 2005, 5 (09) : 667 - 667
[45] Complete Alternative Splicing Events Are Bubbles in Splicing Graphs
Sammeth, Michael
JOURNAL OF COMPUTATIONAL BIOLOGY, 2009, 16 (08) : 1117 - 1140
[46] ALTERNATIVE SPLICING TO TISSUE SPECIFIC SPLICING - AN EVOLUTIONARY PATHWAY
BRODY, E
MARIE, J
GOUXPELLETAN, MS
DORVAL, BC
EVOLUTIONARY TINKERING IN GENE EXPRESSION, 1989, 169 : 203 - 213
[47] A novel Splicing Factor that Affects Titin Alternative Splicing
Guo, Wei
Greaser, Marion
Li, Shijun
Schulz, Herbert
Saar, Kathrin
Radke, Michael
Hacker, Timothy A.
Saupe, Kurt W.
Vakeel, Padmanabhan
Govindarajan, Thirupugal
Hubner, Norbert
Gotthardt, Michael
BIOPHYSICAL JOURNAL, 2011, 100 (03) : 287 - 287
[48] The Alternative Splicing Mutation Database: A hub for investigations of alternative splicing using mutational evidence
Bechtel J.M.
Rajesh P.
Ilikchyan I.
Deng Y.
Mishra P.K.
Wang Q.
Wu X.
Afonin K.A.
Grose W.E.
Wang Y.
Khuder S.
Fedorov A.
BMC Research Notes, 1 (1)
[49] Assessing conservation of alternative splicing with evolutionary splicing graphs
Zea, Diego Javier
Laskina, Sofya
Baudin, Alexis
Richard, Hugues
Laine, Elodie
GENOME RESEARCH, 2021, 31 (08) : 1462 - +
[50] Possible participation of pICln in the regulation of angiogenesis through alternative splicing of vascular endothelial growth factor receptor rnRNAs
Li, H
Yonekura, H
Kim, CH
Sakurai, S
Yamamoto, Y
Takiya, T
Futo, S
Watanabe, T
Yamamoto, H
ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH, 2004, 11 (5-6): : 293 - 300

← 1 2 3 4 5 →