Synergistic enhancement effect of magnetic nanoparticles on anticancer drug accumulation in cancer cells

被引：57
|
作者：
Zhang, Renyun
Wang, Xuemei [1 ]
Wu, Chunhui
Song, Min
Li, Jingyuan
Lv, Gang
Zhou, Jian
Chen, Chen
Dai, Yongyuan
Gao, Feng
Fu, Degang
Li, Xiaomao
Guan, Zhiqun
Chen, Boan
机构：
[1] SE Univ, Chien Shiung Wu Lab, State Key Lab Bioelect, Nanjing 210096, Peoples R China
[2] SE Univ, Zhongda Hosp, Sch Clin Med, Nanjing 210096, Peoples R China
[3] Univ Saarland, Dept Phys, D-66041 Saarbrucken, Germany
来源：
NANOTECHNOLOGY | 2006年 / 17卷 / 14期
关键词：
D O I：
10.1088/0957-4484/17/14/043
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Three kinds of magnetic nanoparticle, tetraheptylammonium capped nanoparticles of Fe3O4, Fe2O3 and Ni have been synthesized, and the synergistic effect of these nanoparticles on the drug accumulation of the anticancer drug daunorubicin in leukaemia cells has been explored. Our observations indicate that the enhancement effect of Fe3O4 nanoparticles is much stronger than that of Fe2O3 and Ni nanoparticles, suggesting that nanoparticle surface chemistry and size as well as the unique properties of the magnetic nanoparticles themselves may contribute to the synergistic enhanced effect of the drug uptake of targeted cancer cells.
引用
收藏
页码：3622 / 3626
页数：5
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