The occurrence of venous thromboembolism in cancer patients following major surgery

Background: Venous thromboembolism (VTE), encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE), is common in cancer patients and surgery is an important risk factor. Objective: To describe the occurrence of VTE in cancer patients following major surgery and to determine the risk of VTE recurrence. Methods: Using the administrative health claims (RAMQ) and hospital discharge (MED-ECHO) databases of the province of Quebec, Canada, we constructed a cohort of all individuals with incident VTE between January 1, 1994 and December 31, 2004 diagnosed with cancer and who had major surgery in the 91 days prior to the VTE. The timing of VTE after surgery was determined. Recurrent VTE was defined as re-hospitalization with a principal discharge diagnosis of VTE. Results: Our cohort consisted of 2706 cancer patients with VTE following major surgery. The mean age was 65.9 years (Standard Deviation 12.6) and 54% were female. The median duration of surgical hospitalization was 18 days (range 1-735 days). The median time to VTE following surgery was 15 days (range 1-659 days), and 34% of VTE events were diagnosed after hospital discharge. The 1-year cumulative rate of recurrence was 6.7% (95% CI 5.7, 7.9) and the 5-year cumulative rate was 12.6% (95% CI 10.7, 14.7). Increasing comorbidity (adjusted hazard ratio (HR) 2.49, 95% CI 1.58-3.95) and VTE diagnosed after hospital discharge (adjusted HR 1.48, 95% CI 1.09-2.01) were associated with recurrence. Conclusions: A significant proportion of VTE episodes among surgical patients with cancer are diagnosed after discharge from hospital. This suggests that surgical patients with cancer are at risk for VTE beyond the immediate postoperative period. (c) 2012 Elsevier Ltd. All rights reserved.