Nonstabilized azomethine ylides as reagents for alkylaminomethylation of aromatic ketones via 5-aryloxazolidines

被引：20
|
作者：
Moshkin, Vladimir S. [1 ]
Buev, Evgeny M. [1 ]
Sosnovskikh, Vyacheslav Y. [1 ]
机构：
[1] Ural Fed Univ, Inst Nat Sci, Dept Chem, Ekaterinburg 620000, Russia
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 38期
基金：
俄罗斯科学基金会;
关键词：
Carbonyl compounds; Nonstabilized azomethine ylides; 3+2] Cycloaddition; 5-Aryloxazolidines; 2-Amino-1-arylethanols; ONE-POT SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; CACTUS ALKALOIDS; ALCOHOLS; DECARBOXYLATION; DERIVATIVES; ALDEHYDES; SARCOSINE;
D O I：
10.1016/j.tetlet.2015.07.068
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Aromatic ketones were found to react smoothly with nonstabilized azomethine ylides, generated in situ from sarcosine/formaldehyde or N-(methoxymethyl)-N-(trimethylsilylmethyl)benzylamine, to give 5-aryloxazolidines which were converted into 2-alkylaminoethanols in moderate to good yields by heating in n-butanol with hydrochloric acid. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5278 / 5281
页数：4
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