A first-in-human phase I/II clinical trial assessing novel mRNA-lipoplex nanoparticles for potent cancer immunotherapy in patients with malignant melanoma

被引：5
|
作者：
Jabulowsky, Robert A.
Loquai, Carmen
Diken, Mustafa
Kranz, Lena M.
Haas, Heinrich
Attig, Sebastian
Bidmon, Nicole
Buck, Janina
Derhovanessian, Evelyne
Diekmann, Jan
Fritz, Daniel
Jahndel, Veronika
Kemmer-Brueck, Alexandra
Kuehlcke, Klaus
Kuhn, Andreas N.
Langguth, Peter
Luxemburger, Ulrich
Meng, Martin
Mueller, Felicitas
Rae, Richard
Sari, Fatih
Schwarck-Kokarakis, Doreen
Seck, Christine
Spiess, Kristina
Witt, Meike
Hassel, Jessica C.
Utikal, Jochen
Kaufmann, Roland
Kreiter, Sebastian
Huber, Christoph
Tuereci, Oezlem
Sahin, Ugur
机构：
来源：
CANCER RESEARCH | 2016年 / 76卷
关键词：
D O I：
10.1158/1538-7445.AM2016-CT032
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
CT032
引用
收藏
页数：4
相关论文
共 50 条
  • [21] First human phase I trial of plasmid IL-12 electro, gene therapy in patients with malignant melanoma.
    Daud, AI
    DeConti, RC
    Messina, JL
    Urbas, PA
    Andrews, S
    Ugen, KE
    Puleo, CA
    Sondak, VK
    Riker, AI
    Heller, R
    CLINICAL CANCER RESEARCH, 2005, 11 (24) : 9119S - 9119S
  • [22] A first-in-human phase I/II trial of SRA737 (a Chk1 Inhibitor) in subjects with advanced cancer.
    Plummer, Elizabeth Ruth
    Kristeleit, Rebecca Sophie
    Cojocaru, Elena
    Haris, Noor Md
    Carter, Louise
    Jones, Robert Hugh
    Blagden, Sarah Patricia
    Evans, T. R. Jeffry
    Arkenau, Hendrik-Tobias
    Sarker, Debashis
    Danson, Sarah
    Symeonides, Stefan N.
    Walter, Harriet
    Ocen, Joanita
    Randhawa, Manreet
    Kowalski, Mark Marion
    Verdon, Ines
    Dye, Andrew
    Banerji, Udai
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
  • [23] A phase I clinical trial investigating the therapeutic cancer vaccine UV1 in combination with pembrolizumab as first-line treatment of patients with malignant melanoma
    Agarwala, S. S.
    O'Day, S. J.
    Zakharia, Y.
    Voorhies, B.
    Milhem, M.
    ANNALS OF ONCOLOGY, 2019, 30
  • [24] A first-in-human phase I/II trial of the oral HIF-2a inhibitor PT2977 in patients with advanced RCC
    Jonasch, E.
    Plimack, E. R.
    Bauer, T.
    Merchan, J. R.
    Papadopoulos, K. P.
    McDermott, D. F.
    Michaelson, M. D.
    Appleman, L. J.
    Thamake, S.
    Zojwalla, N.
    Choueiri, T. K.
    ANNALS OF ONCOLOGY, 2019, 30
  • [25] A first-in-human phase I trial of NB003, a potent and selective KIT/PDGFRa inhibitor, in patients with advanced gastrointestinal stromal tumors (GIST)
    Chi, P.
    Shen, L.
    Li, J.
    Zhang, J.
    Hu, K.
    Zhang, L.
    Xu, Y.
    ANNALS OF ONCOLOGY, 2023, 34 : S1031 - S1031
  • [26] Gene therapy with plasmid IL-12 delivered by electroporation in patients with malignant melanoma: Results of first human Phase I trial
    Heller, R.
    DeConti, R.
    Messina, J.
    Andrews, S.
    Urbas, P.
    Ugen, K.
    Puleo, C.
    Sondak, V.
    Riker, A.
    Daud, A.
    EJC SUPPLEMENTS, 2006, 4 (12): : 106 - 106
  • [27] FIRST-IN-HUMAN PHASE I CLINICAL TRIAL OF ONCOLYTIC DELTA-24-RGD (DNX-2401) WITH BIOLOGICAL ENDPOINTS: IMPLICATIONS FOR VIRO-IMMUNOTHERAPY
    Lang, Frederick F.
    Conrad, Charles
    Gomez-Manzano, Cande
    Tufaro, Frank
    Yung, W. K. A.
    Sawaya, Raymond
    Weinberg, Jeffrey
    Prabhu, Sujit
    Fuller, Gregory
    Aldape, Kenneth
    Fueyo, Juan
    NEURO-ONCOLOGY, 2014, 16
  • [28] Phase I, first-in-human trial of LV305 in patients with advanced or metastatic cancer expressing NY-ESO-1.
    Somaiah, Neeta
    Block, Matthew Stephen
    Kim, Joseph W.
    Shapiro, Geoffrey
    Hwu, Patrick
    Eder, Joseph Paul
    Jones, Robin Lewis
    Gnjatic, Sacha
    Lu, Hailing
    Hsu, Frank James
    Pollack, Seth
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [29] A phase II clinical trial of a novel combinatorial antitumor immunotherapy for patients with high-risk resected stage III and metastatic melanoma.
    Riker, A. I.
    Alsfeld, L. C.
    Harrison, M.
    Foxworth, D.
    Lee, Q.
    Rossi, G. R.
    Tennant, L.
    Ramsey, W. J.
    Vahanian, N. N.
    Link, C. J.
    JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)
  • [30] BreAK CRC, a first-in-human phase I/II trial of STC-1010, a new allogenic cancer vaccine for advanced or metastatic unresectable colorectal cancer
    You, Benoit
    Italiano, Antoine
    Hollebecque, Antoine
    Awada, Ahmad
    Sclafani, Francesco
    Tosi, Diego
    Cassier, Philippe Alexandre
    Christenson, Eric
    Tougeron, David
    Erol, David P. Prime
    Tortorelli, Corinne
    Pinteur, Benoit
    Chalus, Lionel
    Alzeeb, George
    Bravetti, Paul
    Ghiringhelli, Francois
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
12345