Does antithymocyte globulin have a place in reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation?

被引：13
|
作者：
Siddiqi, Tanya [1 ]
Blaise, Didier [2 ]
机构：
[1] City Hope Natl Med Ctr, Dept Hematol Hematopoiet Cell Transplantat, Duarte, CA 91010 USA
[2] Inst J Paoli I Calmettes, Dept Hematol, Programme Transplantat & Therapie Cellulaire, Marseilles, France
来源：
HEMATOLOGY-AMERICAN SOCIETY HEMATOLOGY EDUCATION PROGRAM | 2012年
关键词：
VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; UNRELATED-DONORS; PROPHYLAXIS; MALIGNANCIES; TRIAL;
D O I：
10.1182/asheducation-2012.1.246
中图分类号：
G40 [教育学];
学科分类号：
040101 ; 120403 ;
摘要：
A 63-year-old male patient without siblings is treated for acute myeloid leukemia with poor prognostic cytogenetics. Despite achieving a first complete remission, he relapsed within the first year of diagnosis. He then achieved a second complete remission. A search for an HLA-identical unrelated donor identified a 10/10 possible match. The patient has several comorbidities (hematopoietic stem cell comorbidity index = 3) and it is recommended that he undergo a reduced-intensity conditioning regimen for allogeneic peripheral blood stem cell transplantation. The patient is well-read on allogeneic stem cell transplantation and asks you the merits of antithymocyte globulin that you propose to include in the conditioning regimen.
引用
收藏
页码：246 / 250
页数：5
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