Single and Combined Effects of Estrone and 17β-Estradiol on Male Goldfish

被引：5
|
作者：
Yan Zhen Hua [1 ]
Lu Guang Hua [1 ]
Yang Xiao Fan [1 ]
机构：
[1] Hohai Univ, Key Lab Integrated Regulat & Resources Dev Shallo, Minist Educ, Coll Environm, Nanjing 210098, Jiangsu, Peoples R China
来源：
BIOMEDICAL AND ENVIRONMENTAL SCIENCES | 2013年 / 26卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Vitellogenin; DNA damage; EROD activity; Carassius auratus; WIDESPREAD SEXUAL DISRUPTION; WATER TREATMENT PLANTS; RIVER NANJING SECTION; IN-VIVO; SEA BASS; ENVIRONMENTAL ESTROGENS; VITELLOGENIN INDUCTION; STEROIDAL ESTROGENS; GONADAL DEVELOPMENT; CARASSIUS-AURATUS;
D O I：
10.3967/0895-3988.2013.03.004
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Objective To assess the single and combined effects of estrone (E-1) and 17 beta-estradiol (E-2) on goldfish (Carassius auratus). Methods Batch tests were conducted. Serum levels of vitellogenin (VTG) and E-2, gonadosomatic indices (GSI), gonadal DNA damage and liver 7-ethoxyresorufin-O-deethylase (EROD) activity were measured after exposure for 14 days. Results The VTG level increased significantly in a concentration-dependent manner. The serum E-2 level was significantly higher and the GSI level was significantly lower in goldfish after exposed to the 3 drugs. DNA damage occurred in treated samples and EROD activity was significantly suppressed 7 days after exposure. The joint effect of E-1 and E-2 was additive with regard to VTG induction. Conclusion The results of our study highlight a series of effects of steroidal estrogens on goldfish. Further study is needed to confirm their effect as a whole.
引用
收藏
页码：176 / 184
页数：9
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