Organocatalytic formal [2+2] cycloaddition initiated by vinylogous Friedel-Crafts alkylation: enantioselective synthesis of substituted cyclobutane derivatives

被引：51
|
作者：
Duan, Guo-Jian [1 ]
Ling, Jun-Bing [1 ]
Wang, Wei-Ping [1 ]
Luo, Yong-Chun [1 ]
Xu, Peng-Fei [1 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 41期
关键词：
DIELS-ALDER REACTIONS; BONDING CATALYSIS; ALDOL REACTION; ALDEHYDES; INDOLE; SCEPTRIN; AGENT;
D O I：
10.1039/c3cc41785a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An organocatalytic vinylogous Friedel-Crafts alkylation-initiated formal [2+2] cycloaddition was successfully developed based on tandem iminium-enamine activation of enals. Transformable pyrrole-functionalized cyclobutanes with three contiguous stereo-centers were readily obtained with excellent levels of regio-, diastereo- and enantiocontrol.
引用
收藏
页码：4625 / 4627
页数：3
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