Construction of 9H-Pyrrolo[1,2-a]indoles by a Copper-Catalyzed Friedel-Crafts Alkylation/Annulation Cascade Reaction

被引：28

作者：

Sun, Yongqing ^{[1
]}

Qiao, Yu ^{[1
]}

Zhao, Haiying ^{[1
]}

Li, Baoguo ^{[1
]}

Chen, Shufeng ^{[1
]}

机构：

[1] Inner Mongolia Univ, Dept Chem & Chem Engn, Inner Mongolia Key Lab Fine Organ Synth, Hohhot 010021, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 23期

基金：

中国国家自然科学基金;

关键词：

CONDENSED N-HETEROCYCLES; INDOLES; DERIVATIVES; CYCLOADDITIONS; ACCESS;

D O I：

10.1021/acs.joc.6b02143

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and concise Cu(OTf)(2)-catalyzed Friedel Crafts alkylation/annulation cascade reaction of substituted indoles with 1,2-dicarbony1-3-enes has been established. This reaction uses readily available starting materials and is operationally simple, thus representing a practical method for the construction of diverse 9H-pyrrolo[1,2-a]indoles bearing a carbonyl group.

引用

页码：11987 / 11993

页数：7

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