Construction of 9H-Pyrrolo[1,2-a]indoles by a Copper-Catalyzed Friedel-Crafts Alkylation/Annulation Cascade Reaction

被引：28
|
作者：
Sun, Yongqing [1 ]
Qiao, Yu [1 ]
Zhao, Haiying [1 ]
Li, Baoguo [1 ]
Chen, Shufeng [1 ]
机构：
[1] Inner Mongolia Univ, Dept Chem & Chem Engn, Inner Mongolia Key Lab Fine Organ Synth, Hohhot 010021, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 23期
基金：
中国国家自然科学基金;
关键词：
CONDENSED N-HETEROCYCLES; INDOLES; DERIVATIVES; CYCLOADDITIONS; ACCESS;
D O I：
10.1021/acs.joc.6b02143
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and concise Cu(OTf)(2)-catalyzed Friedel Crafts alkylation/annulation cascade reaction of substituted indoles with 1,2-dicarbony1-3-enes has been established. This reaction uses readily available starting materials and is operationally simple, thus representing a practical method for the construction of diverse 9H-pyrrolo[1,2-a]indoles bearing a carbonyl group.
引用
收藏
页码：11987 / 11993
页数：7
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