Adding folate to the contraceptive pill: a new concept for the prevention of neural tube defects

被引：8

作者：

Holzgreve, Wolfgang ^{[1
]}

Pietrzik, Klaus ^{[2
]}

Koletzko, Berthold ^{[3
]}

Eckmann-Scholz, Christel ^{[4
]}

机构：

[1] Inst Adv Res, Berlin, Germany

[2] Univ Bonn, Inst Ernahrungs & Lebensmittelwissensch, Bonn, Germany

[3] Univ Munich, Med Ctr, Dr von Hauner Childrens Hosp, Munich, Germany

[4] Univ Hosp Schleswig Holstein, Dept Obstet & Gynecol, Kiel, Germany

来源：

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2012年 / 25卷 / 09期

关键词：

Folate application; neural tube defects; oral contraceptives; FOLIC-ACID SUPPLEMENTATION; PERICONCEPTIONAL MULTIVITAMIN SUPPLEMENTATION; CONGENITAL-ABNORMALITIES; DIETARY-FOLATE; WOMEN; PREGNANCY; DISCONTINUATION; MALFORMATIONS; FORTIFICATION; ASSOCIATION;

D O I：

10.3109/14767058.2011.648672

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Although it is proven for a long time that folic acid supplementation in the periconceptional period can prevent neural tube defects (NTDs) effectively, all measures taken so far including food fortification and awareness campaigns so far had only limited success. Since more than 50% of the pregnant women in Europe get pregnant after they have used oral contraceptives (OCs) before, OCs are an ideal vehicle to increase not only the awareness for periconceptional folate application, but they can also help to bridge the gap between the recognition of a pregnancy and closure of the neural tube which is before day 26. In order to reach a truly protective folate level at the critical time period during pregnancy, now OCs are available which contain metafolin. The availability of this innovative type of OC will significantly reduce the number of NTDs.

引用

页码：1529 / 1536

页数：8

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