Parallel independent evolution of pathogenicity within the genus Yersinia

被引：118

作者：

Reuter, Sandra ^{[1
,2
]}

Connor, Thomas R. ^{[2
,3
]}

Barquist, Lars ^{[2
]}

Walker, Danielle ^{[2
]}

Feltwell, Theresa ^{[2
]}

Harris, Simon R. ^{[2
]}

Fookes, Maria ^{[2
]}

Hall, Miquette E. ^{[1
]}

Petty, Nicola K. ^{[2
,4
]}

Fuchs, Thilo M. ^{[5
]}

Corander, Jukka ^{[6
]}

Dufour, Muriel ^{[8
]}

Ringwood, Tamara ^{[9
]}

Savin, Cyril ^{[11
]}

Bouchier, Christiane ^{[12
]}

Martin, Liliane ^{[11
]}

Miettinen, Minna ^{[6
]}

Shubin, Mikhail ^{[6
]}

Riehm, Julia M. ^{[13
]}

Laukkanen-Ninios, Riikka ^{[7
]}

Sihvonen, Leila M. ^{[14
]}

Siitonen, Anja ^{[14
]}

Skurnik, Mikael ^{[15
,16
]}

Falcao, Juliana Pfrimer ^{[17
]}

Fukushima, Hiroshi ^{[18
]}

Scholz, Holger C. ^{[13
]}

Prentice, Michael B. ^{[9
]}

Wren, Brendan W. ^{[19
]}

Parkhill, Julian ^{[2
]}

Carniel, Elisabeth ^{[11
]}

Achtman, Mark ^{[10
,20
]}

McNally, Alan ^{[1
]}

Thomson, Nicholas R. ^{[2
,19
]}

机构：

[1] Nottingham Trent Univ, Pathogen Res Grp, Nottingham NG11 8NS, England

[2] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[3] Cardiff Univ, Sch Biosci, Cardiff CF10 3AX, S Glam, Wales

[4] Univ Technol Sydney, Ithree Inst, Sydney, NSW 2007, Australia

[5] Tech Univ Munich, Zent Inst Ernahrungs & Lebensmittelforsch, D-85350 Freising Weihenstephan, Germany

[6] Univ Helsinki, Dept Math Sci, FIN-00014 Helsinki, Finland

[7] Univ Helsinki, Dept Food Hyg & Environm Hlth, Fac Vet Med, FIN-00014 Helsinki, Finland

[8] Inst Environm Sci & Res, Upper Hutt 5140, New Zealand

[9] Natl Univ Ireland Univ Coll Cork, Dept Microbiol, Cork, Ireland

[10] Natl Univ Ireland Univ Coll Cork, Environm Res Inst, Cork, Ireland

[11] Inst Pasteur, Yersinia Res Unit, F-75724 Paris, France

[12] Inst Pasteur, F-75724 Paris, France

[13] Bundeswehr Inst Microbiol, Dept Bacteriol, D-80937 Munich, Germany

[14] Natl Inst Hlth & Welf THL, Bacteriol Unit, FIN-00271 Helsinki, Finland

[15] Univ Helsinki, Dept Bacteriol & Immunol, Haartman Inst, FIN-00014 Helsinki, Finland

[16] Helsinki Univ Cent Hosp Lab Diagnost, FIN-00014 Helsinki, Finland

[17] Univ Sao Paulo, Brazilian Reference Ctr Yersinia Spp Other Y Pest, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Sao Paulo, Brazil

[18] Shimane Prefectural Inst Publ Hlth & Environm Sci, Matsue, Shimane 6990122, Japan

[19] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

[20] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2014年 / 111卷 / 18期

基金：

英国生物技术与生命科学研究理事会; 芬兰科学院; 英国惠康基金;

关键词：

genomics metabolic streamlining; pathoadaptation; Enterobacteriaceae; POPULATION-STRUCTURE; BACTERIAL PATHOGENS; VIRULENCE PLASMID; ELECTRON-ACCEPTOR; ANAEROBIC GROWTH; EPITHELIAL-CELLS; GENOME SEQUENCE; ENTEROCOLITICA; PESTIS; SALMONELLA;

D O I：

10.1073/pnas.1317161111

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The genus Yersinia has been used as a model system to study pathogen evolution. Using whole-genome sequencing of all Yersinia species, we delineate the gene complement of the whole genus and define patterns of virulence evolution. Multiple distinct ecological specializations appear to have split pathogenic strains from environmental, nonpathogenic lineages. This split demonstrates that contrary to hypotheses that all pathogenic Yersinia species share a recent common pathogenic ancestor, they have evolved independently but followed parallel evolutionary paths in acquiring the same virulence determinants as well as becoming progressively more limited metabolically. Shared virulence determinants are limited to the virulence plasmid pYV and the attachment invasion locus ail. These acquisitions, together with genomic variations in metabolic pathways, have resulted in the parallel emergence of related pathogens displaying an increasingly specialized lifestyle with a spectrum of virulence potential, an emerging theme in the evolution of other important human pathogens.

引用

页码：6768 / 6773

页数：6

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