A one-pot, pseudo four-component synthesis of novel benzopyrano[2,3-b]pyridines under solvent-free conditions

被引：20
|
作者：
Olyaei, Abolfazl [1 ]
Vaziri, Mohsen [1 ]
Razeghi, Reza [1 ]
机构：
[1] Payame Noor Univ, Dept Chem, Tehran, Iran
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 15期
关键词：
Naphthol; Benzopyranopyridine; Malononitrile; Aldehyde; Knoevenagel condensation; NAD(+)-DEPENDENT DNA-LIGASE; BIS-SCHIFF BASES; CONVENIENT; FLINDERSINE; PRODUCTS; PROTEIN; SYSTEM;
D O I：
10.1016/j.tetlet.2013.01.124
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile, one-pot, pseudo four-component catalyst- and solvent-free synthesis of novel benzopyrano[2,3-b]pyridines is achieved by Michael addition of various naphthols to iminocoumarin derivatives obtained from Knoevenagel condensation of salicylaldehydes with malononitrile, which can be attacked by another molecule of malononitrile to afford the title products. The advantages of this procedure are mild reaction conditions, high yields of products, generality, short reaction times and operational simplicity. (C) 2013 Published by Elsevier Ltd.
引用
收藏
页码：1963 / 1966
页数：4
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