Open Label Single-Arm Clinical Trial with Earvaru Beeja Kalka in the Management of Benign Prostatic Hyperplasia

Benign prostatic hypertrophy (BPH) is a common condition in the aging men along with lower urinary tract symptoms (LUTS). The prevalence of BPH is proportional to age. It affects 70% of men above 70 years. It is the increase in the number of stromal and glandular epithelial cells in the periurethral transitional zone of the prostate. It can be correlated to vatashtila one among the mutraghata. BPH can be managed by a conservative and surgical treatment which includes anti-androgen therapy, alpha-blockers, aromatase inhibitors, prostatectomy, laser therapy, microwave treatment. As the patients are fairly old these complications are liable to occur in early postoperative days. Even conservative therapy has disadvantages like administering anti-androgen therapy causes impotence, aromatase inhibitors which are widely used have to lead to certain side effects like lassitude, depression, gynecomastia. According to surveys, the socioeconomic burden of BPH is tremendous, costing over $3 billion every year. In this situation, Ayurveda may be able to provide a treatment that is herbal and free from any adverse effects. This research work was carried out with the ultimate aim of finding the best cost-effective treatment of BPH in comparison with available Allopathic treatment. An extensive literature review reveals that Ervaru beeja kalka along with saindhava lavana and dhanyamla is an excellent remedy for mutraghata. Ervaru beeja kalka is an excellent mutrala, balya and dosha prashamana. Also, studies reveal that chemical constituents in cucumber seed can act on the signaling pathway of the proliferation of cancer cells i n the prostate. Because of all these reasons, the present study of Earvaru beeja kalka on BPH was done.