CX3CL1 at the crossroad of EGF signals Relevance for the progression of ERBB2+ breast carcinoma

被引：11

作者：

Tardaguila, Manuel ^{[1
]}

Manes, Santos ^{[1
]}

机构：

[1] CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, Madrid, Spain

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 09期

关键词：

chemokine; cross-activation; ERK; fractalkine; inflammation; MAPK; tumor promotion; RECEPTOR TRANSACTIVATION; CHEMOKINE; IDENTIFICATION; FRACTALKINE; THERAPY; CANCER; TARGET;

D O I：

10.4161/onci.25669

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inflammatory mediators can play a dual role in oncogenesis and tumor progression. CX3CL1, a chemokine previously implicated in natural killer cell- and CD8(+) T cell-mediated antitumor immune responses, has now been identified as a promoter of ERBB2-expressing breast carcinomas as it cross-activates members of the epidermal growth factor receptor family.

引用

页数：3

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