Access to β-Keto Esters by Palladium-Catalyzed Carbonylative Coupling of Aryl Halides with Monoester Potassium Malonates

被引：46
|
作者：
Korsager, Signe [1 ,2 ]
Nielsen, Dennis U. [1 ,2 ]
Taaning, Rolf H. [1 ,2 ]
Skrydstrup, Troels [1 ,2 ]
机构：
[1] Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, Ctr Insoluble Prot Struct inSPIN, DK-8000 Aarhus C, Denmark
[2] Aarhus Univ, Dept Chem, DK-8000 Aarhus C, Denmark
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 37期
基金：
新加坡国家研究基金会;
关键词：
beta-keto esters; carbonylation; homogeneous catalysis; isotope labeling; palladium; STOICHIOMETRIC CARBON-MONOXIDE; EX-SITU; ACYLATION; ALKOXYCARBONYLATION; GENERATION; SYSTEM; ACIDS;
D O I：
10.1002/anie.201304072
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New tricks for an old dog: The Pd-catalyzed carbonylative α-arylation of monoethyl potassium malonates with aryl bromides and reactive aryl chlorides provides a simple and direct route to aryl β-ketoesters. Because only stoichiometric amounts of carbon monoxide are employed, the method is ideal for the introduction of carbon isotopes into more complex structures. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：9763 / 9766
页数：4
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